Cognitive Impairment and Prognosis in Patients With Decompensated Heart Failure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- cognitive function in decompensated heart failure patients measured by a cognitive test battery
研究概览
简要总结
The aim of the present study is threefold: investigating 1) specific cognitive impairments in patients with congestive heart failure, 2) whether cognitive impairments in patients with decompensated heart failure improve after medical recompensation and 3) whether cognitive functioning is related to the long-term prognosis (mortality, rehospitalisation) of those patients.
详细描述
The daily routine in clinical settings often shows cognitive impairments in patients with congestive heart failure. Recent studies reported declines in cognitive functioning such as executive functions, episodic memory, perceptual speed and attention. However, less is known regarding the differential impairments of cognitive functioning in patients with decompensated heart failure.
Study objectives:
- Identifying specific cognitive impairments in patients with congestive heart failure compared to healthy controls
- Evaluating the influence of acute decompensation in congestive heart failure on cognitive functioning
- Investigating the effects of medical treatment on cognitive functioning in patients with decompensated heart failure
- Exploring long-term effects of cognitive and physiological status on hospitalisation and/or mortality
Study design:
Cognitive functions of patients with decompensated heart (NYHA III-IV) failure are compared to age and gender matched patients with congestive heart failure (NYHA III-IV) without symptoms of cardiac decompensation and with healthy controls. Decompensated patients are tested before and after medical recompensation. For matched patients and controls, the pretest-posttest timing is based on the recompensation time of the respective patient with decompensated heart failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •decompensated heart failure patients
- •NYHA III-IV
- •ejection fraction < 35%
排除标准
- •psychosis
- •major depression
- •reanimation (<3month)
- •patients with assist device system
研究组 & 干预措施
decompensated heart failure patients
干预措施: diuretics, inotropica (Drug)
结局指标
主要结局
cognitive function in decompensated heart failure patients measured by a cognitive test battery
时间窗: within 48h of hospitalisation
cognitive function before and after medical recompensation measured by a cognitive test battery
时间窗: individual time to recompensate
differences in cognitive performance between decompensated heart failure patients, patients with chronic heart failure and healthy controls
时间窗: 14 months (+/-2 month)
次要结局
- long-term development of cognitive functioning in patients with heart failure after acute decompensation(3, 6, 12 and 18 months after acute decompensation)
- all cause mortality(12 month)