Effect of CI on Prognosis in the Elderly Patients With ACS

• Conditions: Cognitive Impairment; Elderly; Acute Coronary Syndrome
• Interventions: Diagnostic Test: MMSE and MoCA

• Registration Number: NCT04278911
• Lead Sponsor: Beijing Friendship Hospital

Brief Summary

This study aims to investigate the incidence and characteristics of cognitive Impairment(CI) in the elderly patients with acute coronary syndrome (ACS), and to determine whether CI are predictive of the prognosis of major adverse cardiovascular events (MACE) and mortality.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Status Verified: 2020-02
• Study First Submitted: 2020-02-19
• Study First Submitted QC: 2020-02-19
• Last Update Submitted: 2020-02-19
• Study First Posted: 2020-02-20
• Last Update Posted: 2020-02-20
• Primary Completion: 2022-01-01
• Study Completion: 2022-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• ≥65yr
• Confirmed ACS diagnosis （include unstable angina, ST-segment elevation myocardial infarction and Non ST-segment elevation myocardial infarction）
• fulfilled MMSE or MoCA
• patients agreed and provided informed consent

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Exclusion Criteria

• Type 2 myocardial infarction and Acute nonischemic myocardial injury
• past history of malignant tumors
• Past history of stroke or dementia
• Hepatic insufficiency (ALT>8ULN or ALT>3ULN and TBIL>2ULN)
• Renal insufficiency (GFR<15 ml/min/1.73m2)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Participates	MMSE and MoCA	This is an observational study

Primary Outcome Measures

Name	Time	Method
MACE (major adverse cardiovascular events)	12 months	Myocardial infarction, revascularization, stroke, cardiac death, all cause of death

Secondary Outcome Measures

Name	Time	Method
Cognitive level decline	12 months	Evaluate MoCA (Montreal Cognitive Assessment).

Trial Locations

Locations (1)

Beijing Friendship Hospital, Capital Medical University; 🇨🇳 Beijing, Beijing, China