Feasibility Study of a Community Pilot Project for the Prevention of Alzheimer's Disease: the KetoHome Study.

Not Applicable

Completed

Interventions: Dietary Supplement: Regular diet
Dietary Supplement: low carb diet

Brief Summary: The purpose of this study is to assess whether it is possible to carry out a research project with a nutritional intervention in senior's residence. Life in a small community is very different and above all unique, which could be an asset in a research setting.

Detailed Description: To ensure its functioning, the brain needs a lot of energy. However, during aging, it has difficulty properly using its main fuel, sugar. The brain then becomes "starved". This energy deficit is part of the vicious circle leading to memory problems. The brain, like a hybrid car, can run on two fuels, sugar and ketones. Providing alternative fuel to the brain, in the form of ketones, and thus offsetting the energy it needs, could improve its functioning and help prevent or improve memory problems.

There are several ways to increase ketones in our body such as certain dietary oils, natural health products, physical activity or certain diets. Reducing the amount of sugar in our diet is also a strategy that can increase ketones. A low-sugar diet is already widely used in the prevention of several important diseases, including type 2 diabetes and even Alzheimer's disease.

This study will assess the feasibility of a community intervention project in a seniors' residence with the eventual overall objective of slowing the progression or onset of AD and related health indicators, through a dietary modification.

This feasibility study will last 6 months. The basic characteristics of interested participants will be collected. The global spheres of evaluation are the following: metabolic profile, cognition, quality of life and nutritional status. Glucose measurements will be taken continuously via a sensor over two weeks during the project.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

The minimum possible criteria ensuring the safety of voluntary participants. The family doctor will need to confirm eligibility.
Body mass index < 22
Malnutrition.
High risk of hypoglycaemia
Moderate to severe digestive diseases that can be aggravated by dietary changes
Severe dysphagia
Supplementation with MCT oil, ketone salts, ketone ester, adherence to the ketogenic diet, intermittent fasting, or other diet or supplements that may significantly increase ketones;
Participation in other intervention research projects on nutrition or aimed at metabolic change simultaneously.

Arm && Interventions

Group	Intervention	Description
10 days control diet	Regular diet	Participants stay on their regular diet while glucose is continuously monitored, heart rate and number of steps is measured for 10 days.
10 days low carb diet	low carb diet	Participants will eat a low carb diet while glucose is continuously monitored, heart rate and number of steps is measured for 10 days.

Primary Outcome Measures

Name	Time	Method
Blood glucose concentrations	over 10 days	in mmol/L

Secondary Outcome Measures

Name	Time	Method
Number of steps	8 hours a day during 10 days
Heart rate	8 hours a day during 10 days	beats per minutes

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