Diagnostic study on retinal amyloid deposition and dementia development in glaucoma patients

Not Applicable

• Conditions: Glaucoma

• Registration Number: JPRN-UMIN000049245
• Lead Sponsor: Tohoku University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-10-18
• Last Update Posted: 17 October 2023
• Study Completion: 2025-03-31

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

Not provided

Exclusion Criteria

1.Those who have severe dysphagia and have difficulty taking curcumin supplements 2.Alcohol addiction, drug addiction patients 3.Those who cannot follow the protocol of this study such as oral administration and fundus examination due to severe cognitive decline. 4.Those who have been administered corticosteroids within 1 month 5.Those with gallbladder disease, gallstones, gastrointestinal disorders 6.Those who have been diagnosed with angle-closure glaucoma and have difficulty in mydriasis 7.Those who cannot perform visual field test or OCT, those who have difficulty in fundus examination and cannot see through the fundus with SLO 8.Those who have severe vision loss (need assistance in daily life due to visual impairment) 9.Those who are judged by the principal investigator or research coordinator to be unsuitable for participation in the research 10.Pregnant women, lactating women, those who wish to become pregnant during the research period

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences between glaucoma patients, cataract patients and healthy subjects regarding the parameters obtained by retinal amyloid imaging

Secondary Outcome Measures

Name	Time	Method
Correlation between parameters acquired by retinal amyloid imaging and cognitive function according to glaucoma severity (glaucoma subgroup analysis)