Imaging the retina for early diagnosis in Alzheimer's disease
- Conditions
- Alzheimer's diseasedementia10042258
- Registration Number
- NL-OMON50349
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 40
-Study cases: patients with alzheimer's disease fulfilling the National
Institute of Neurological and Communicative Disorders and Stroke and the
Alzheimer's Disease and Related Disorders Association (NINCDS/ADRDA) criteria.
-Controls: age and gender matched controls with Subjective Memory
Complaints(SMC) and/or AMD (Age related Macula Degeneration) and no evidence of
amyloid pathology according to CSF or amyloid PET scan analysis.
-Patients need to be fully capacitated and able to give informed consent
themselves, with an mini-mental state examination (MMSE)-score of at least
17/30.
+ Subject with ophthalmological conditions:
- Media opacities interfering with optimal imaging
- Narrow angle (with risk of acute angle close glaucoma)
- History of glaucoma, uveitis, retinal detachment, retinal dystrophy)
- History of chronic illness, with chronic medication, like reuma, sarcoidosis,
inflammatory bowel disease, diabetes mellitus
- Recent ocular surgery within 6 months prior to study examinations
- Any ocular surgery of the vitreous / retina (vitrectomy, retinal detachment,
macular hole, pucker). Late stages of Age related Macular Degeneration (AMD) or
extensive drusen in the retina
+ MMSE <=16
+SMC with Aβ-pathologie
+ Multiple sclerosis, Parkinson's disease or other neurodegenerative diseases
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Detection of Aβ-plaques in the retina of AD patients.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Comparison of Aβ-plaques in the retina with other AD biomarkers. Analysis of<br /><br>sensitivity and specificity.</p><br>