anguage and EEG characteristics in brain tumour patients: Can we predict language outcome after surgery?

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 90

Inclusion Criteria

Patient group 1:
- Diagnosis of a radiologically presumed low-grade glioma; according to the judgement of radiologist, neurosurgeon or neurologist.
- Location in the language dominant hemisphere (if unknown: right-handed and left-sided tumour)
- Tumour is untreated
- Planned to undergo awake brain surgery
- In case of epilepsy, seizures under control with anti-epileptic drugs (less than six seizures in the previous year and on anti-epileptic monotherapy or polytherapy)
- Between 18 and 75 years old;Patient group 2:
- Diagnosis of an intracranial, supratentorial meningioma
- Location in the left hemisphere
- Location: falcine and parasaggital meningiomas, when located at the skull base only sphenoid wing, and tentorial meningiomas when located supratentorially
- Diameter > 3 cm
- Tumour is untreated
- Planned to undergo brain surgery
- Presumed low-grade
- Language dominance in the left or right hemisphere
- In case of epilepsy, seizures under control with anti-epileptic drugs (less than six seizures in the previous year and on anti-epileptic monotherapy or polytherapy)
- Between 18 and 75 years old;Control group (comparable to the patient groups with respect to age, gender and education):
- right-handed
- between 18 and 75 years old

Exclusion Criteria

For the patient groups:
- Non-native speaker of Dutch or insufficient command of the Dutch language
- History of a medical, neurological or psychiatric condition known to affect language or cognitive functioning
- (History of) substance abuse
- Use of medication known to influence language or cognitive functioning, other than anti-epileptic drugs
- Use of dexamethasone pre-operatively (peri-operatively according to local protocol is not an exclusion criterion)
- Use of medication known to influence EEG, other than anti-epileptic drugs
- Previous brain surgery or cranial radiation therapy;For the control group:
- Non-native speaker of Dutch or insufficient command of the Dutch language
- History of medical, neurological or psychiatric condition known to affect language or cognitive functioning
- (History of) substance abuse
- Use of medication known to influence language or cognitive functioning
- Use of medication known to influence EEG
- Previous brain surgery or cranial radiation therapy

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Language abilities of low-grade glioma and meningioma patients before<br /><br>surgery, shortly after surgery, and at the long-term follow-up.<br /><br>- The relation between language functioning and resting-state EEG<br /><br>characteristics in brain tumour patients.<br /><br>- Pre-operative EEG characteristics that predict language outcome after brain<br /><br>tumour surgery.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Network characteristics that are associated with specific linguistic deficits.<br /><br>- Associations between language and performance in other cognitive domains.<br /><br>- The relation between the severity of the language disorder and the quality of<br /><br>life in brain tumour patients before and after surgery.</p><br>