Predictive Nature of Total Cholesterol Threshold: Possible Link to Suicidal Behavior
- Conditions
- Current Major Depressive Disorder
- Interventions
- Other: patient's routine care
- Registration Number
- NCT02847741
- Lead Sponsor
- University Hospital, Montpellier
- Brief Summary
Suicidal behavior (SB) is a public health problem. The clinical model currently admitted to the understanding of SB is a stress vulnerability model, but so far, all scientific works has no clinical application. The management of psychiatric patients, including depressed subjects, faces the inability to detect those with a high risk of SB. Many studies have shown a link between low cholesterol and SB. A study has recently proposed a total cholesterol threshold below which the risk of suicide could be increased. However, a prospective study is needed to assess the predictive nature of such an indicator.
- Detailed Description
Investigators propose to assess, within a cohort of patients, the predictive value of a total cholesterol threshold in the occurrence of SB.
555 inpatients suffering from a current Major depressive disorder (MDD), hospitalized in the Department of Emergency Psychiatry and Post Acute Care will be recruited.
Each patient will attend a total of 5 visits during a follow-up period of 18 months (visits at 1, 3, 6, 12, and 18 months)
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 555
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Major depressive episode patient's routine care Depressive patients will be assessed by interview (psychiatrists), questionnaires and blood sampling, as the inpatients's routine care
- Primary Outcome Measures
Name Time Method frequency of suicide attempts at 18 month frequency of suicide attempts during the 18months follow-up, according to the total cholesterol threshold at baseline. The biological sampling is carried out after 12 hours of fasting.
- Secondary Outcome Measures
Name Time Method depression (Quick Inventory of Depressive Symptomatology) at 18 month Studying the relation between score to the Quick Inventory of Depressive Symptomatology and the occurrence of new SB during the 18 months follow-up
score to the brixton test at 18 month Studying the relation between score to the brixton test (assessment of mental flexibility) and the response to antidepressant treatment during the 18 months follow-up
relation between inflammatory markers and the occurrence of SB at 18 month Studying the relation between inflammatory markers at baseline and the occurrence of new SB during the 18 months follow-
relation between thyroid function and the occurrence of SB at 18 month Studying the relation between thyroid function at baseline and the occurrence of new SB during the 18 months follow-up
moral pain at 18 month Studying the relation between moral pain (assessed by Likert scale from 0 to 10) at baseline and the response to antidepressant treatment during the 18 months follow-up
history of childhood abuse at 18 month Studying the relation between an history of childhood abuse (assessed by the childhood trauma questionnaire) and the response to antidepressant treatment during the 18 months follow-up
scores to Iowa Gambling Task Time frame: 18 months at 18 month Studying the relation between scores to the Iowa Gambling Task (assessment of decision making) and the occurrence of new SB during the 18 months follow-up
scores to the Attentional Stroop test at 18 month Studying the relation between scores to Attentional Stroop test and the response to antidepressant treatment during the 18 months follow-up
depression level (Inventory of Depressive Symptomatology) at 18 month Studying the relation between score to the Inventory Of Depressive Symptomatology and the response to antidepressant treatment during the 18 months follow-up
National Adult Reading Test score ( NART) at 18 month Studying the relation between NART score (assessment of intellectual level ) and the response to antidepressant treatment during the 18 months follow-up
verbal fluency at 18 month Studying the relation between score to verbal fluency and the response to antidepressant treatment during the 18 months follow-up
number of past SB at 18 month Studying the relation between the number of past SB (assessed by the Columbia Suicide History Form) and the occurrence of new SB during the 18 months follow-up
scores to verbal fluency at 18 month Studying the relation between scores to verbal fluency and the occurrence of SB during the 18 months follow-up
scores to Reversal Learning Task at 18 month Studying the relation between scores to Reversal learning task (assessment of decision making) and the response to antidepressant treatment during the 18 months follow-up
relation between pharmacological assays and the occurrence of SB at 18 month Studying the relation between pharmacological assays at baseline and the occurrence of new SB during the 18 months follow-up
relation between the characteristic of the mood depressive disorder (unipolar or bipolar depression) and the predictive or vulnerability factors of SB at 18 month Studying the potential specificity of predictive or vulnerability factors of SB depending on whether the diagnosis is unipolar or bipolar depression
relation between thyroid function and the response to antidepressant treatment at 18 month Studying the relation between thyroid function at baseline and the response to antidepressant treatment during the 18 months follow-up
depression level (Quick Inventory of Depressive Symptomatology) at 18 month Studying the relation between score to the Quick Inventory of Depressive Symptomatology and the response to antidepressant treatment during the 18 months follow-up
physical pain at 18 month Studying the relation between physical pain (assessed by Likert scale from 0 to 10) at baseline and the response to antidepressant treatment during the 18 months follow-up
suicidal ideation at 18 month Studying the relation between suicidal ideation (assessed by the Columbia Suicide Severity Rating Scale, the Scale of Suicidal Ideation) and the response to antidepressant treatment during the 18 months follow-up
National Adult Reading Test score at 18 month Studying the relation between NART score (assessment of intellectual level) and the occurrence of new SB during the 18 months follow-up
scores to California Verbal Learning Test at 18 month Studying the relation between scores to California Verbal Learning Test (assessment of verbal memory) and the response to antidepressant treatment during the 18 months follow-up
the characteristic of past SB at 18 month Studying the relation between the number and the lethality of past SB (assessed by the Columbia Suicide History Form, the Risk Rescue Rating Scale, the Suicidal Intent Scale ) and the response to antidepressant treatment during the 18 months follow-up
scores to Iowa Gambling Task at 18 month Studying the relation between scores to Iowa Gambling Task (assessment of decision making) and the response to antidepressant treatment during the 18 months follow-up
relation between lipid profile and the response to antidepressant treatment at 18 month Studying the relation between lipid profile at baseline and the response to antidepressant treatment during the 18 months follow-up
lethality of past SB at 18 month Studying the relation between the lethality of past SB (assessed by the Columbia Suicide History Form) and the occurrence of new SB during the 18 months follow-up
Depression (Inventory of Depressive Symptomatology) at 18 month Studying the relation between score to the Inventory Of Depressive Symptomatology and the occurrence of new SB during the 18 months follow-up
depression level (Beck depression Inventory) at 18 month Studying the relation between score to the Beck depression Inventory and the response to antidepressant treatment during the 18 months follow-up
relation between lipid profile and the occurrence of SB at 18 month Studying the relation between lipid profile at baseline and the occurrence of new SB during the 18 months follow-up
relation between inflammatory markers and the response to antidepressant treatment at 18 month Studying the relation between inflammatory markers at baseline and the response to antidepressant treatment during the 18 months follow-up
Depression (Beck Depression Inventory) at 18 month Studying the relation between score to the Beck Depression Inventory and the occurrence of new SB during the 18 months follow-up
relation between pharmacological assays and the response to antidepressant treatment at 18 month Studying the relation between pharmacological assays at baseline and t the response to antidepressant treatment during the 18 months follow-up
Trial Locations
- Locations (1)
Montpelleir University Hospital
🇫🇷Montpellier, France