Effects of mirror therapy on the excitability of the motor cortex in healthy individuals and stroke patients.

Not Applicable

Recruiting

• Conditions: I60; I61; I63; I64; Subarachnoid haemorrhage; Intracerebral haemorrhage; Cerebral infarction; Stroke, not specified as haemorrhage or infarction

• Registration Number: DRKS00033890
• Lead Sponsor: urija Institut Kliniken Schmieder Allensbach

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

I. Healthy subjects:
1. Ability to give informed consent to participate in the study
2. Age > 18 years
3. No history of neurological or psychiatric illness
4. Not taking any medication known to affect the excitability of the brain (e.g. benzodiazepines)

II. Patients
1. Ability to give consent to participate in the study
2. Age > 18 years
3. Sufficient understanding of the task
4. No or minor pain in the affected arm, measured by visual analog scale
5. First stroke (ischemia or hemorrhage), not longer than 6 months ago
6. Rehabilitation phase C or D
7. Paresis of the upper limb with a strength level of 3 to 4+ or impairment of fine motor skills

Exclusion Criteria

I. Healthy subjects:
1. Participants with electronic implants (e.g. pacemakers)
2. Epilepsy
3. Pregnancy
4. Intracranial metal particles (e.g. vascular clips)

II. Patients
1. Cognitive impairments that do not allow information about the study (e.g. Wernicke's aphasia, global aphasia, dementia)
2. Participants with poor compliance
3. Pain
4. Participants with electronic implants (e.g. pacemakers)
5. Epilepsy
6. Pregnancy
7. Intracranial metal particles (e.g. vascular clips)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TMS parameters (derivation from the interosseus dorsalis I muscle; stimulation with the butterfly coil): Single stimulus amplitudes, short- and long-latency intracortical inhibition, intracortical facilitation.

Secondary Outcome Measures

Name	Time	Method
1. Mental chronometry with the box and block test (comparison of motor execution and motor imagery).<br>2. Vividness of movement imagery questionnaire (German version).<br>3. Examination of somatosensory functions (vibration sensation, proprioceptive test), as severely impaired sensitivity has a negative impact on the ability to perform mental chronometry and could therefore also have an influence on mirror perception.<br>4 Edinburgh Handedness Inventory.