NCT00525850已完成不适用
Effect of High Saturated Fat No Starch Diet vs. Low Saturated Fat, Low Trans Fat, High Fiber Diet on Weight Loss and Markers of Atherosclerotic Cardiovascular Disease
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Weight loss
研究概览
简要总结
To evaluate two different diets and their effects on weight loss and measurements of several risk factors for cardiovascular disease. One diet will be a high saturated fat diet (HSFD) and the other is a low saturated fat diet (LSFD) that limits fat but especially saturated fat as red meat. All participants in this study must eat both diets as this is a randomized cross-over design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •In order to qualify, participants must have metabolic syndrome:
- •triglycerides greater than 150 mg/dL
- •blood pressure greater than 130 mmHg and/or diastolic blood pressure greater than 85 mmHg
- •fasting glucose greater than 110 mg/dL
- •waist circumference greater than 40 inches in men or 35 inches in women
- •reduced HDL less than 40 mg/dL in men and less than 50 mg/dL in women. Participants must be capable of performing symptom-limited maximal exercise capacity study. Blood and urine samples collected at baseline will be analyzed for CBC, serum glucose and electrolytes, hepatic panel and TSH.
排除标准
- •Participants will be excluded for any significant blood dyscrasia, fasting glucose greater than 200 mg/dL, creatine greater than 2 mg/dL, any significant electrolyte disorder, hepatic functions greater than two times normal or abnormal TSH.
研究组 & 干预措施
1
Other
high saturated fat diet
干预措施: high fat diet (Other)
2
Other
low calorie low saturated fat low trans fat high fiber diet
干预措施: low saturated fat diet (Other)
结局指标
主要结局
Weight loss
时间窗: 12 weeks
次要结局
- Brachial artery reactivity(12 weeks)
研究者
研究点 (2)
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