Obstetric Anesthesia and Analgesia and Multiple Sclerosis

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Data search

• Registration Number: NCT03247894
• Lead Sponsor: Brno University Hospital

Brief Summary

Aim of the retrospective study was to evaluate the influence of the labour on the clinical course of the parturients with MS in selected 6 month follow-up interval and to evaluate to possible influence of the different anesthesia/analgesia types on the course of MS.

Detailed Description

The role of anesthesia in multiple sclerosis (MS) progression remains unclear in spite of few foreign studies. The most frequently afflicted patients by MS are women of childbearing age and influence of anesthesia or obstetric epidural analgesia has only not been investigated in Czech Republic. The study aims to retrospectively compare the further course of the disease of MS in patients who labor between 2004 and 2013 in University Hospital Brno either by caesarean section or vaginally with epidural analgesia , with patients who gave birth spontaneously without anesthesia.The aim of the study was to evaluate the influence of the labour on the clinical course of MS and further evaluate the possible influence of the type of anesthesia/analgesia in the peripartal period on the MS progression.

Study Timeline

• Study Start: 2014-08-01
• Primary Completion: 2017-07-31
• Study Completion: 2017-08-01
• Study First Submitted: 2017-08-04
• Study First Submitted QC: 2017-08-09
• Study First Posted: 2017-08-14
• Status Verified: 2019-05
• Last Update Submitted: 2019-05-25
• Last Update Posted: 2019-05-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

• Parturients with multiple sclerosis
• Possible follow up - neurologic examination available after 10 month from delivery

Exclusion Criteria

• probable or no multiple sclerosis at time of labor
• unknown neurology history
• unknown data on neurology outcome 6 months after labour
• Incomplete data
• Follow-up not possible

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MS patients who after labour	Data search	Patients with multiple sclerosis after labour in tertiary center was screened for progression of MS in 10 months period after labour

Primary Outcome Measures

Name	Time	Method
Multiple sclerosis decompensation/progression	3 months after labour	Relapse occurence from labour to 6 months after delivery
Multiple sclerosis decompensation/progression at 3rd month	3 months after labour	Relapse occurence from labour to 3 months, after delivery was recorded. A relapse was defined as the appearance or worsening of symptoms of neurologic dysfunction lasting more than 24 hours, new lesions on MRI or need of reinforcement in treatment. For disease state after delivery we used dichotomic approach: relapse (at least one) or no relapses.

Secondary Outcome Measures

Name	Time	Method
MS progression and the type of anesthetic method	6 months after labour	MS progression comparison due to the type of anethesia

Trial Locations

Locations (1)

Brno University Hospital; 🇨🇿 Brno, Czechia, 62500, Czechia