Effectiveness of a Bundle of Ventilator Associated Pneumonia (VAP) Prevention in the Pediatric Intensive Care Unit (PICU): an Observational Study
试验速览
- 阶段
- 不适用
- 入组人数
- 242
- 试验地点
- 1
- 主要终点
- VAP incidence
研究概览
简要总结
This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of Fondazione Policlinico Agostino Gemelli of 8 beds. The investigators will compare the incidence of VAP in the group of patients in which this protocol has been implemented to a retrospective control group of patients before the new protocol implementation. VAP bundle includes oral care hygiene measures (i.e chlorhexidine swab), to keep clean and dry ventilator circuits and head positioning at 45 degrees.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age < 18 years
- •patients receiving mechanical ventilation for more than 48 hours
排除标准
- •no informed consent
- •pregnancy
- •previous endotracheal antibiotic therapy
结局指标
主要结局
VAP incidence
时间窗: From 48 hours after intubation to 48 hours after extubation
Incidence of VAP in pediatric patients intubated for more than 48 hours
次要结局
- Prevalence of orotracheal bacterial colonization in ventilated patients(From 48 hours after intubation to 48 hours after extubation)
研究者
Orazio Genovese
Medical Doctor, pediatric intensive care unit
Fondazione Policlinico Universitario Agostino Gemelli IRCCS