Micro Array Analysis in Preeclampsia

Assistance Publique Hopitaux De Marseille1 site in 1 country40 target enrollmentJune 15, 2011

Overview

Preeclampsia is a frequent pathology. His etiology is doubtful.

Targets :

The study target is to identify a risk of preeclampsia group obtained with transcriptom analysis from circulating peripheric cells.

Design:

Multidisciplinary study (Gynaecology-Obstetric, Immunology, North CIC).

The study of the transcriptional history of peripheral blood cells of 2patients groups:

A patient group with a preeclampsia before 34 SA
A patient group with a normal pregnancy paired on main confusion factors. Blood sampling will be collected at the diagnosis and 8 weeks after delivery.

Results and perspectives

Obtain a transcriptionnal signature of preeclampsia
To identify new mechanism of the disease
Identification of a specific transcriptom analysis with the comparison after delivery For long-term, the target is to identify risk patient in order to conduct easily preventive clinical trials in preeclamsia (primary prevention) and to consider a specific follow-up for risk patients.

Registry

clinicaltrials.gov

Start Date

June 15, 2011

End Date

January 25, 2021

Last Updated

5 years ago

Study Type

Interventional

Study Design

Parallel

Sex

Female

Sponsor

Responsible Party

Sponsor

•A prééclampsie (blood pressure superior to 140 mmHg and to 90 mmHg) and at least a cross of protein in the strip and/or more of 300mg / 24h after 20 LIMITED COMPANIES and before 34 limited companies.
•An informed consent signed by the patient will necessarily have to be obtained.
•Woman having been taken care during the pregnancy or at the time of the childbirth(delivery) by one of the participating teams to the current project.
•Caucasian Patient
•Wait primigeste and nullipare

•Major Patient protected by the law.
•Patient deprived of freedom for administrative or judicial reasons.
•Patient not benefiting from a national insurance scheme.
•Refusal of the patient to participate in the study.
•Not Caucasian Patient
•Multipare Wait
•Multiple Pregnancy
•Existence of foetal deformation explaining a delay of growth or a foetal death in utero.
•Age 18 years and \> 40 years.
•Absence of written consent or impossibility to receive the written consent (language or understanding).