Shivering and Glucose Homeostasis
Not Applicable
Completed
- Conditions
- Healthy Overweight/Obese
- Registration Number
- NCT04516018
- Lead Sponsor
- Maastricht University
- Brief Summary
The purpose of this study is to investigate the effect of prolonged shivering thermogenesis on glucose homeostasis in overweight/obese humans.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Signed informed consent
- Caucasian
- Healthy (as determined by dependent physician based on medical questionnaire)
- Man, or postmenopausal (defined as at least 1year post cessation of menses) woman
- Aged 40 - 75 years at the start of the study
- BMI 27 and 35 kg/m2
- Stable dietary habits (no weight loss or gain >3kg in the past 3 months)
Exclusion Criteria
-
- Not meeting all inclusion criteria
- Medication use known to hamper subject's safety during study procedures
- Co-morbidities to which the intervention or program that may pose as a complicating factor
- Subjects diagnosed with cardiovascular diseases or cancer
- Fasting plasma glucose ≥ 7.0 mmol/l
- Haemoglobin < 7.8 mmol/l for women, or < 8.4 mmol/l for men
- Previously diagnosed with type 2 diabetes
- Abuse alcohol/drug abuse
- Subjects who do not want to be informed about unexpected medical findings during the screening/study or do not wish that their physician is informed.
- Engagement in structured exercise > 2h per week
- Participation in another biomedical study within 1 month before the first study
- Smoking
- Cold-acclimated, such as takes daily extended cold baths, works in a refrigerated environment, or regular cold-water swimming within 1 month of starting the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method area under the curve (AUC) of the glucose tolerance test 1 day following cold exposure and following 9 consecutive days of cold exposure area under the curve (AUC) of the glucose tolerance test before cold exposure, 1 day after cold exposure and after 9 consecutive days of cold exposure.
- Secondary Outcome Measures
Name Time Method skeletal muscle GLUT4 translocation 1 day following cold exposure and following 9 consecutive days of cold exposure Comparison between skeletal muscle GLUT4 translocation, as assessed by wide-field microscopy both before and after cold acclimation
Trial Locations
- Locations (1)
Maastricht University
🇳🇱Maastricht, Limburg, Netherlands
Maastricht University🇳🇱Maastricht, Limburg, Netherlands