The Effect of Different Physical Activity Strategy on Cognitive Efficiency and Mental Fatigue Resistance During a Simulated Mental Working Day
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Biochemical urine analysis
研究概览
简要总结
The main aim of this biomedical study is to determine the effect of moderate-intensity aerobic exercise, before and after an 8-hour workday and a combined work model, on the performance and efficiency of cognitive functions during mental work.
There are lack of previous studies analysing the effects of different physical activity strategies on cognitive efficiency and investigating mental fatigue resistance. Limited research in this area shows that the mechanism of the effect of physical activity on mental fatigue resistance is still unclear. This research will aim to investigate different physical activity strategies, such as combined work model and moderate intensity physical activity before and after office workday, and their impact on a mental and emotional fatigue, cognitive efficiency, sympathetic and parasympathetic systems and metabolic indicators during mentally demanding 8 h workday.
详细描述
Prolonged sedentary behavior and sustained cognitive workload during typical office workdays contribute significantly to the onset of acute mental fatigue (Kunasegaran et al., 2023). This condition is linked to physiological mechanisms such as reduced cerebral blood flow, diminished glucose availability and transport to active brain regions (García et al., 2021; Kennedy & Scholey, 2000), as well as hormonal alterations (Miyashita & Williams, 2006; Wiehler et al., 2022). These changes negatively impact cognitive efficiency, motivation, and overall brain function (Kunasegaran et al., 2023; Tran et al., 2020). While existing evidence supports the positive influence of physical activity on physical and mental health (Calderwood et al., 2021; Jacquet et al., 2021), there remains a lack of research specifically examining how different physical activity strategies influence cognitive efficiency and resistance to mental fatigue.
This study aims to address this gap by investigating the effects of various physical activity interventions, including a combined work-exercise model and moderate-intensity aerobic exercise performed either before or after an 8-hour mentally demanding workday. Outcomes will focus on mental and emotional fatigue, cognitive efficiency, autonomic nervous system activity (sympathetic and parasympathetic balance), and metabolic responses. By evaluating these parameters, the study seeks to clarify the potential of targeted physical activity strategies to enhance mental fatigue resistance and support cognitive performance in occupational settings. The findings are expected to contribute valuable insight into the development of effective workplace interventions that promote employee well-being, productivity, and resilience.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI from 18.5 to 24.9 kg/ m2;
- •No chronic non-communicable diseases;
- •No mental illnesses or disorders;
- •No cancer and no chemotherapy in the last 5 years;
- •No hearing impairment;
- •No smoking;
- •No psychotropic substances;
- •Heart rate (HR) about 60 bpm at rest;
- •Unimpaired color vision;
- •Unimpaired or corrected vision;
- •Systolic blood pressure from 90 to 139 mmHg, and diastolic - from 50 to 89 mmHg at rest.
排除标准
- •mental, oncological, metabolic, cardiovascular, skeletal, muscular, respiratory system disorders or diseases, impaired color vision.
研究组 & 干预措施
Control
Healthy young subjects will participate in research "control" condition attending 8 h simulated working day. During simulated working day subjects will perform cognitive tasks (ANAM4, version 4; Vista Life Science, Norman, OK, USA) for 8 times (1 session 11 tests about 45 min). The effect of a mental workday on cognitive function indicators will be evaluated. Same participants will participate in 3 research trials (control, aerobic activity and combined work model).
干预措施: 8 hours simulated mental workday (Other)
Aerobic activity
Healthy young subjects will participate in research "aerobic activity" condition attending 8 h simulated working day. Subjects will cycle 30 min on a veloergometer in a 50 % of maximal capacity before the cognitive tasks and after them (before and after simulated 8 h workday). During simulated working day subjects will perform cognitive tasks (ANAM4, version 4; Vista Life Science, Norman, OK, USA) for 8 times (1 session 11 tests about 45 min).
The effect of a moderate-intensity aerobic physical activity before and after 8 hours of a mental workday will be evaluated. Same participants will participate in 3 research trials (control, aerobic activity and combined work model).
干预措施: 8 hours simulated mental workday (Other)
Aerobic activity
Healthy young subjects will participate in research "aerobic activity" condition attending 8 h simulated working day. Subjects will cycle 30 min on a veloergometer in a 50 % of maximal capacity before the cognitive tasks and after them (before and after simulated 8 h workday). During simulated working day subjects will perform cognitive tasks (ANAM4, version 4; Vista Life Science, Norman, OK, USA) for 8 times (1 session 11 tests about 45 min).
The effect of a moderate-intensity aerobic physical activity before and after 8 hours of a mental workday will be evaluated. Same participants will participate in 3 research trials (control, aerobic activity and combined work model).
干预措施: Moderate intensity aerobic activity (Other)
Combined work model
Healthy young subjects will participate in research "combined work model" condition attending 8 h simulated working day. Subjects will perform cognitive tasks applying combined work model, which means that participants will be changing their positions from sitting on a balance ball to standing while performing cognitive tasks. During simulated working day subjects will perform cognitive tasks (ANAM4, version 4; Vista Life Science, Norman, OK, USA). The effect of a the combined work model on cognitive functions indicators during a simulated 8 h mental working day will be evaluated. Same participants will participate in 3 research trials (control, aerobic activity and combined work model).
干预措施: 8 hours simulated mental workday (Other)
Combined work model
Healthy young subjects will participate in research "combined work model" condition attending 8 h simulated working day. Subjects will perform cognitive tasks applying combined work model, which means that participants will be changing their positions from sitting on a balance ball to standing while performing cognitive tasks. During simulated working day subjects will perform cognitive tasks (ANAM4, version 4; Vista Life Science, Norman, OK, USA). The effect of a the combined work model on cognitive functions indicators during a simulated 8 h mental working day will be evaluated. Same participants will participate in 3 research trials (control, aerobic activity and combined work model).
干预措施: Combined work model (Other)
结局指标
主要结局
Biochemical urine analysis
时间窗: 2 times during 1 condition (total 6 times).
The urine sample will be analyzed in the laboratory using a urine analyzer (PocketChem UA, PU-4010, Arkray, Koji, Konan-cho, Koka-shi, Japan). The analyzer will determine the concentrations of ketones.
Ketones level (mmol/L)
时间窗: 9 times during 1 condition (total 27 times).
Ketones level will be measured from capillary blood using a ketone analyzer (The On Call® GK Dual; San Diego, CA; USA). Capillary blood samples will be taken by a qualified medical professional (general practice nurse) at the LSU Institute of Sports Science and Innovation laboratory.
Body mass and body composition (kg)
时间窗: 2 times in the mornings (day 1 and day 2) of each 3 conditions.
Body mass and composition (in kilograms) will be evaluated using Tanita Body Composition Analyzer (Japan).
Height (m)
时间窗: 2 times in the mornings (day 1 and day 2) of each 3 conditions.
Height (in meters) will be measured using a Harpenden anthropometer set (Holtain Ltd, UK).
Cognitive performance
时间窗: Day 1 in 3 different conditions, in 1 condition 8 times for 45 minutes.
Automated Neuropsychological Assessment Metrics Test Set (ANAM4, version 4; Vista Life Science, Norman, OK, USA). 11 tests will be selected, reflecting the three main cognitive functions - memory, attention and executive function. 11 tests: Procedural RT, Memory search, Spatial processing simultaneous, Matching grids, Matching to sample, Stroop colour word test, Code substitution-learning and Code substitution-delayed, Running memory continuous performance, Continous performance test - traditional. To assess cognitive performance, during a simulated 8-hour mental work day, the subjects will complete a set of cognitive tests 8 times (1 session approximately 45 minutes), after each session there will be a break of approximately 10 minutes. Participants were familiarized with the test battery twice before the experiments.
Brain hemodynamic response
时间窗: Before, immediately after the simulated mental workday, 3 hours after the simulated mental workday, and 12 hours recovery after a simulated mental workday in 3 conditions.
To measure and evaluate hemodynamic response, a functional near-infrared (fNIRS) device NIRx NIRS Sport2 (Medical Technologies LLC-NIR-Scout, USA) with 8 near-infrared (NIR) radiation sources and 7 photodetectors will be used. The photodetectors record the relative changes in oxygen and oxygenated hemoglobin at 7.81 Hz for both wavelengths. The probes are placed at the manufacturer's specified locations to capture the hemodynamic response of the prefrontal cortex. Live recording will be monitored for 6 minutes.
Blood pressure (mmHg)
时间窗: 11 times during 1 condition (total 33 times).
Systolic and diastolic blood pressure (in mmHg) will be measured using a blood pressure monitor (Biolight, Patient Monitor S10, Guangdong Biolight Meditech Co, Hamburg, Germany).
Heart rate and heart rate variability (ms)
时间窗: During 1 condition rest measurements in the morning, during brain hemodynamic response (3 times during 1 condition), during every session of 8 hours simultaneous mental work day, total 3 conditions.
Heart rate (HR) will be recorded using a heart rate monitor (Polar H10, Kempele, Finland) with an electrode strap around the chest throughout the study. 5-min RR interval file will then be analyzed using Kubios HR Variability Analysis Software 2.0 (Biomedical Signal and Medical Image Analysis Group, Department of Applied Physics, University of Kuopio, Kuopio, Finland).
Glucose level (mmol/l)
时间窗: 9 times during 1 condition (total 27 times).
Glucose level will be measured from capillary blood using Akray glucose analyzer (CONTOUR®PLUS ELITE; Basel, Switzerland). Capillary blood samples will be taken by a qualified medical professional (general practice nurse) at the LSU Institute of Sports Science and Innovation laboratory.
Salivary cortisol concentration (µg/dl)
时间窗: 11 times during 1 condition (total 33 times).
The saliva samples will be collected to measure cortisol level (in µg/dl) using an ELISA kits and a Spark multimode microplate reader (Tecan, Austria).
Lactate level (mmol/L)
时间窗: 9 times during 1 condition (total 27 times).
Lactate levels will be measured using a lactate analyzer (Lactatte Pro 2, Arkray, Koji Konan-cho, Koka-shi, Japan). Capillary blood samples will be taken by a qualified medical professional (general practice nurse) at the LSU Institute of Sports Science and Innovation laboratory.
Salivary testosterone concentration (µg/dl)
时间窗: 11 times during 1 condition (total 33 times).
The saliva samples will be collected to measure cortisol level (in µg/dl) using an ELISA kits and a Spark multimode microplate reader (Tecan, Austria).
Salivary female sex hormones concentration (pgmol/L)
时间窗: 11 times during 1 condition (total 33 times).
The saliva samples will be collected to measure cortisol level (in µg/dl) using an ELISA kits and a Spark multimode microplate reader (Tecan, Austria).
Pupil diameter (mm)
时间窗: Before and 3 times during simulated 8 hours workday in 1 condition (total 12 times).
The dilation and contraction of the pupils of the test subjects' eyes will be recorded using a special camera (Gazepoint, Vancouver, Canada), which will be placed under the computer screen, in front of the subject.
The psycho-emotional state: Dundee Stress State Questionnaire (DSSQ)
时间窗: Before and 8 times during simulated 8 hours workday in 1 condition (total 27 times).
The psycho-emotional state of the subjects will be assessed using the Dundee Stress State Questionnaire (DSSQ). The DSSQ questionnaire will be used to assess the subjects' motivation in relation to the content of the task, performing a cognitive test battery during the mental work day. 15 questions will be used, e.g.: "the content of the task was interesting", "I wanted to do the task well compared to others", etc. The subject will have to mark the corresponding answers to each question, where 4 (strongly), 3 (very), 2 (a little), 1 (a little), 0 (not at all).
The psycho-emotional state: the VAS scale
时间窗: Before and 8 times during simulated 8 hours workday in 1 condition (total 27 times).
Motivation, mental fatigue and mind wondering will be assessed using a visual analogue scale (VAS). Subjects will mark their feelings on a 10 centimetres horizontal line from 0 ("completely unmotivated"; "not mentally tired"; "no mind wandering") to 100 ("maximum motivated"; "maximum mental fatigue"; "maximum mind wandering").
The psycho-emotional state: Stanford sleepiness scale.
时间窗: Before and 8 times during simulated 8 hours workday in 1 condition (total 27 times).
The Stanford Sleepiness Scale will be used to assess subjects' sleepiness. On this scale, subjects will mark their level of sleepiness from 1 "I feel active, efficient, lively, alert or awake" to 7 "I can no longer fight sleep, I will fall asleep quickly; thoughts are like dreams".
Measurement of maximal aerobic capacity
时间窗: Before.
The maximal aerobic capacity of the subjects will be measured in order to determine the average aerobic load, which will be applied in the study condition "aerobic activity ". The subjects will perform a consistently increasing load until complete fatigue on a bicycle ergometer (Lode B.V., Excalibur Sport, Groningen, Netherlands). Throughout the test, subjects will have their heart rate monitored using a chest strap heart rate monitor (Polar H10, Kempele, Finland). A spirometry system (Metalyzer 3B, Cortex, Leipzig, Germany) will be used to measure oxygen uptake (VO2). VO2max (maximum oxygen uptake) will be considered the highest oxygen uptake during any 15 s of exercise.
Sleep quality assessment
时间窗: 3 days before each condition and during testings.
Sleep (hours of total sleep and sleep stages) will be monitored using a Garmin wrist-worn watch (Vivo fit 4, UK).
Physical activity assessment
时间窗: 3 days before each condition and during testings.
Physical activity (steps per day) will be monitored using a Garmin wrist-worn watch (Vivo fit 4, UK).
次要结局
未报告次要终点