Cognitive-motor Training in Parkinson Disease
- Conditions
- Parkinson Disease
- Interventions
- Other: Cognitive-motor trainingOther: Conventional physiotherapy
- Registration Number
- NCT06588439
- Lead Sponsor
- National Yang Ming Chiao Tung University
- Brief Summary
Literature reviews showed the cognitive-motor training that combines cognitive tasks may enhance cognitive functions more effectively than individual interventions. Stepping-based cognitive-motor training has been shown to improve cognitive functions, balance, and gait performance in older adults. However, there is insufficient research evidence on the impact and correlation of this training mode on the walking ability, executive functions, and brain activity changes in people with PD. Therefore, this study is designed to investigate the effects of stepping-based cognitive-motor training on the walking ability, executive functions, and brain activity in people with PD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
- Diagnoses of idiopathic Parkinson disease
- Stable dopaminergic medicine ≥ 2 weeks
- Able to walk 10 meters without aid
- Mini-Mental Status Examination ≥ 24 points
- No uncorrected visual or auditory disorders
- Education at least junior high school
- No other disease may affect balance
- Other medical diagnoses of neurological, musculoskeletal, or cardiopulmonary disorders
- History of brain surgery (e.g. deep brain stimulation)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cognitive-motor training group Cognitive-motor training Participants receive 16 sessions of cognitive-motor training. Control group Conventional physiotherapy Participants receive 16 sessions of conventional physiotherapy.
- Primary Outcome Measures
Name Time Method Gait variability Before and after 8 weeks of intervention, as well as 4 weeks after intervention Using GAITRite system to measure the coefficient of variation (CV). The mean and standard deviation will be used to calculate the coefficient of variation (CV). CV = standard deviation / mean \* 100%
Gait speed Before and after 8 weeks of intervention, as well as 4 weeks after intervention Using GAITRite system to measure gait speed
Step length Before and after 8 weeks of intervention, as well as 4 weeks after intervention Using GAITRite system to measure step length
Step width Before and after 8 weeks of intervention, as well as 4 weeks after intervention Using GAITRite system to measure step width
Single support time Before and after 8 weeks of intervention, as well as 4 weeks after intervention Using GAITRite system to measure single support time
Double support time Before and after 8 weeks of intervention, as well as 4 weeks after intervention Using GAITRite system to measure double support time
Frontal Assessment Battery Before and after 8 weeks of intervention, as well as 4 weeks after intervention The score ranged from 0 to 18. Higher scores show better executive function.
Stroop color and word test Before and after 8 weeks of intervention, as well as 4 weeks after intervention Record numbers of corrected color words which the subject responds within 45 sec.
Digit span test Before and after 8 weeks of intervention, as well as 4 weeks after intervention Digit span test contain forward and backward part. Scores of forward digit span ranges from 0 to 16. Score of backward digit span ranges from 0 to 14. Higher scores indicate better executive function.
Event-related potential - N2 Before and after 8 weeks of intervention, as well as 4 weeks after intervention Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Event-related potential - P300 Before and after 8 weeks of intervention, as well as 4 weeks after intervention Measure event-related potential through electroencephalography under single-task and dual-task paradigm.
Go/Nogo test Before and after 8 weeks of intervention, as well as 4 weeks after intervention Behavioral test during measuring electroencephalography.
Trail making test Before and after 8 weeks of intervention, as well as 4 weeks after intervention Trail making test contain part A and part B. Faster completing the test indicates better executive function.
- Secondary Outcome Measures
Name Time Method Mini-Balance Evaluation Systems Test Before and after 8 weeks of intervention, as well as 4 weeks after intervention Mini-Balance Evaluation Systems Test scores range from 0 to 28. Higher scores indicate better balance ability.
Montreal Cognitive Assessment Before and after 8 weeks of intervention, as well as 4 weeks after intervention Montreal Cognitive Assessment ranges from 0 to 30. Higher scores reflect better cognitive performances.
Timed up and go test Before and after 8 weeks of intervention, as well as 4 weeks after intervention Record time of performing timed up and go test
Parkinson Disease Questionnaire Before and after 8 weeks of intervention, as well as 4 weeks after intervention Parkinson Disease Questionnaire assess quality of life in people with Parkinson disease. Lower scores reflect higher quality of life.