Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Active, not recruiting

• Conditions: Hydrocephalus; Movement Disorders; Diagnoses Disease; Parkinson Disease; Walking, Difficulty; Gait Ataxia
• Interventions: Diagnostic Test: Dynamic stability measurement

• Registration Number: NCT05998473
• Lead Sponsor: Henri Mondor University Hospital

Brief Summary

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Detailed Description

Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Study Timeline

• Study Start: 2023-06-01
• Status Verified: 2023-08
• Study First Submitted: 2023-08-07
• Study First Submitted QC: 2023-08-16
• Last Update Submitted: 2023-08-16
• Study First Posted: 2023-08-21
• Last Update Posted: 2023-08-21
• Primary Completion: 2023-09-30
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• Age >18 years
• Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement
• Diagnosis of normal pressure hydrocephalus or Parkinson's disease

Exclusion Criteria

• Levodopa drugs administrated during a delay of 12 hours before walking test
• Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Parkinson's disease	Dynamic stability measurement	Patients with a diagnosis of Parkinson's disease and who performed a gait analysis in laboratories
Normal pressure hydrocephalus	Dynamic stability measurement	Patients with a diagnosis of normal pressure hydrocephalus and who performed a gait analysis in laboratories

Primary Outcome Measures

Name	Time	Method
Coefficient of variation in step length	30 seconds	Coefficient of variation in step length during 8-meter comfortable walking test

Trial Locations

Locations (1)

Laboratoire Analyse et Restauration du Mouvement; 🇫🇷 Créteil, France