Early Restricted Oxygen Therapy after Resuscitation from Cardiac Arrest trial
- Conditions
- Post cardiac arrest syndrome
- Registration Number
- JPRN-UMIN000046914
- Lead Sponsor
- Japanese Association for Acute Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 1000
Not provided
Spontaneous circulation on hospital arrival No ventilator use for oxygen administration after return of spontaneous circulation (ROSC) GCS equal to or higher than 8 at the time of ROSC ECMO use at the time of ROSC Survival longer than 24 hours after ROSC is not expected Cardiac arrest due to intracranial diseases Poor neurological function before cardiac arrest (Cerebral Performance Category =3 or 4) COVID-19 requiring medications designated for COVID-19 Withholding or withdrawing critical care at the time of ROSC Severe comorbidity that requires strict titration of oxygen, such as chronic lung diseases and congenital diseases Cardiac arrest due to intoxication is suspected Patients in whom SpO2 cannot be measured correctly Patients who participated in other clinical trials that require a therapeutic intervention Patients who need to be arrested, detained, or put in custody by law enforcement or legal agencies Patients who refuse to participate in the trial Patients deemed by a clinical physician to be ineligible to participate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cerebral Performance Category (CPC) at 90 days after the study intervention
- Secondary Outcome Measures
Name Time Method 30-day mortality, 90-day mortality, hospital-, ICU-, ventilator-, RRT-, and oxygen-free days to day 90, clinical frailty scale at 90 days, hyperoxemia equal to or higher than 300 mmHg in arterial blood within 12 hours, and hypoxia less than 60 mmHg in arterial blood within 12 hours.