The Effect of Probiotic Supplementation with Beetroot on Cardiovascular Functio

Phase 3

• Conditions: Patients with Chronic Heart Failure with reduced Ejection Fraction (HFrEF).; Heart failure, unspecified; I50.9

• Registration Number: IRCT20231225060520N1
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 6 March 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Clinical diagnosis of heart failure with echocardiogram showing systolic dysfunction with ejection fraction = 45% based on New York Heart Association (NYHA) class II-IIID heart failure symptoms with ischemic or non-ischemic etiology
Under standard treatment with drugs
Men and women with age range of 30-70 years
Willingness to participate in the study and complete the informed consent form

Exclusion Criteria

Use of nutritional supplements (oral or injectable, such as vitamins D, C, E, calcium, magnesium, potassium and anti-mineral multivitamin, omega 3) and herbal products with antioxidant and anti-inflammatory properties, probiotic or synbiotic supplements or products containing them during the study
Not consuming more than 20% of the capsules
Unwillingness to continue cooperation in research

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Terminal pro Natriuretic Peptide type B (NT-proBNP). Timepoint: In the beginning of the study (before the start of the intervention) and 60 days after the intervention. Method of measurement: Kit for measuring N-terminal pro-natriuretic peptide type B in venous blood sample.