Associative Memory in Adults With an Autism Spectrum Disorder

Not Applicable

• Conditions: Autistic Disorder
• Interventions: Device: Electroencephalography; Behavioral: Neuropsychological assesments

• Registration Number: NCT02279680
• Lead Sponsor: University Hospital, Caen

Brief Summary

The objective of this multidisciplinary project is to explore the deficit of associative memory in ASD (Autistic Spectrum Disorder) that could result from abnormal brain connectivity. The hypothesis of abnormal functioning of the fronto-hippocampal network has been evocated but has never been tested. Hence, the present project will include two complementary assessments conducted on a group of adults aged from 18 to 30 with ASD compared to a control group matched in chronological age and intellectual quotient. The first assessment is devoted to the study of associative memory and its EEG correlates and the second focused on the investigation of perceptual strategies related to associative memory using the technique of Eye-tracking. Both behavioral and imaging data would provide new insights on the relationship between perception and memory in ASD.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2014-06-23
• Status Verified: 2014-10
• Study First Submitted QC: 2014-10-28
• Last Update Submitted: 2014-10-28
• Study First Posted: 2014-10-31
• Last Update Posted: 2014-10-31
• Primary Completion: 2015-12
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Adult between 18 and 30 years old
• right handed
• affiliated to the french national health care system
• ASD only for the group of patients

Exclusion criteria :

• mental retardation
• schizophrenia
• ADHD
• brain injury with lost of consciousness
• neurological disease

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients	Neuropsychological assesments	Adults between 18 and 30 years old right handing Patients with ASD
Healthy volunteers	Neuropsychological assesments	Adults between 18 and 30 years old Right handing Healthy
Patients	Electroencephalography	Adults between 18 and 30 years old right handing Patients with ASD
Healthy volunteers	Electroencephalography	Adults between 18 and 30 years old Right handing Healthy

Primary Outcome Measures

Name	Time	Method
The associative memory index	2 years

Secondary Outcome Measures

Name	Time	Method
theta and gamma oscillations during the associative memory task	2 years

Trial Locations

Locations (1)

UMR1077 Inserm/EPHE/UCBN; 🇫🇷 Caen, France