Orthostatic Blood Pressure and Arterial Stiffness in Persons With SCI: The Effect of RAAS System
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Arterial Stiffness
- Sponsor
- James J. Peters Veterans Affairs Medical Center
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Pulse Wave Velocity (m/s)
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
Detailed Description
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls. Arterial stiffness and blood pressure will be collected in the laying down position. A blood sample of norepinephrine and plasma renin will also be collected. The participant will tilt to 30, 45 and 60 degrees for 10 minutes at each angel. Blood pressure and heart rate will be monitored at each angle. Another blood sample of renin and norepinephrine will be collected at the end of 10 minutes at 60 degrees.
Investigators
Jill M. Wecht, Ed.D.
Principal Investigator
James J. Peters Veterans Affairs Medical Center
Eligibility Criteria
Inclusion Criteria
- •SCI participants:
- •injured between C1-T1 and T6-T12
- •wheelchair dependent
- •AIS classification A, B or C
- •Injured occurred more than 1 year ago
Exclusion Criteria
- •currently have an illness or infection
- •current smoker of at least 1 year
- •controlled or uncontrolled hypertension or diabetes mellitus
- •Neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease)
- •cardiovascular disease (coronary heart disease, congestive heart failure, peripheral artery disease)
Outcomes
Primary Outcomes
Pulse Wave Velocity (m/s)
Time Frame: 2 years
Determine average pulse wave velocity among the three groups.
Secondary Outcomes
- Systolic Blood Pressure (mmHg)(2 years)
- Plasma Renin (pg/ml)(2 years)
- Norepinephrine (pg/ml)(2 years)