Orthostatic Blood Pressure and Arterial Stiffness in Persons With SCI: The Effect of RAAS System
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Pulse Wave Velocity (m/s)
研究概览
简要总结
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls.
详细描述
The study is examining differences in central arterial stiffness, orthostatic changes in blood pressure, norepinephrine, and plasma renin in individuals with spinal cord injury compared with age-matched uninjured controls. Arterial stiffness and blood pressure will be collected in the laying down position. A blood sample of norepinephrine and plasma renin will also be collected. The participant will tilt to 30, 45 and 60 degrees for 10 minutes at each angel. Blood pressure and heart rate will be monitored at each angle. Another blood sample of renin and norepinephrine will be collected at the end of 10 minutes at 60 degrees.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •SCI participants:
- •injured between C1-T1 and T6-T12
- •wheelchair dependent
- •AIS classification A, B or C
- •Injured occurred more than 1 year ago
排除标准
- •currently have an illness or infection
- •current smoker of at least 1 year
- •controlled or uncontrolled hypertension or diabetes mellitus
- •Neurological condition other than SCI (Alzheimer's disease, dementia, stroke, multiple sclerosis, Parkinson's disease)
- •cardiovascular disease (coronary heart disease, congestive heart failure, peripheral artery disease)
结局指标
主要结局
Pulse Wave Velocity (m/s)
时间窗: 2 years
Determine average pulse wave velocity among the three groups.
次要结局
- Systolic Blood Pressure (mmHg)(2 years)
- Plasma Renin (pg/ml)(2 years)
- Norepinephrine (pg/ml)(2 years)
研究者
Jill M. Wecht, Ed.D.
Principal Investigator
James J. Peters Veterans Affairs Medical Center