Comparison of Longitudinal Blood Pressure and Arterial Stiffness in Preeclamptic and Normotensive Women After Delivery: One-Year Follow-Up Results
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- The differences in longitudinal change pattern of CAVI between preeclampsia and normal pregnant women.
研究概览
简要总结
The investigator measured the arterial stiffness using cardio-ankle vascular index (CAVI) test in patient with preeclampsia and normal pregnant women to evaluate the longitudinal change of CAVI and their predictors.
详细描述
This study was a case control study and included 37 women with preeclampsia (PE group) and 36 normotensive women (control group) who gave birth to child at Seoul National University Bundang Hospital.
Cario-ankle vasuclar index (CAVI) was measured at one day, six months and one year after delivery in both group.
The investigator also checked the body weight, blood pressure, lipid profile, serum creatinine, aspartate transaminase (AST) and alanine transaminase (ALT) simultaneously with CAVI.
The relationship between the presence of preelampsia and longitudinal changes of CAVI, blood pressure and metabolic indices were evaluated using generalized estimating equation (GEE) method.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Case group : Women who were diagnosed preeclampsia based on the criteria of the International Society for the Study of Hypertension in Pregnancy
- •Control group : Normotensive women who gave birth to child at Seoul National University Bundang Hospital.
排除标准
- •Women who were hemodynamically compromised or had bleeding complication after delivery were excluded.
结局指标
主要结局
The differences in longitudinal change pattern of CAVI between preeclampsia and normal pregnant women.
时间窗: The CAVI was measured at one day, six months and one year after delivery in both groups.
The CAVI was analyzed with generalized estimating equation (GEE) method to evaluate the different change pattern of CAVI between two groups.
次要结局
- Diastolic blood pressure(one day, six months and one year after delivery)
- Body weight(one day, six months and one year after delivery)
- Lipid profiles (Total cholesterol, TG, LDL, HDL)(one day, six months and one year after delivery)
- Waist/Hip ratio(one day, six months and one year after delivery)
- Systolic blood pressure(one day, six months and one year after delivery)
- AST(aspartate aminotransferase), ALT(alanine aminotransferase)(one day, six months and one year after delivery)
- Serum creatinine(one day, six months and one year after delivery)
研究者
Jung-Won Suh
Principal investigator
Seoul National University Hospital