Mean Systemic Pressure Measurement During Prone Position Surgery

• Conditions: Hemodynamic Variation During Surgery

• Registration Number: NCT01957605
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Venous return is driven by the pressure gradient between mean systemic pressure and right atrial pressure. However, mean systemic pressure is more a physiological concept than an available clinical measurement. Indeed, the mean systemic pressure is the one that would be measured anywhere within the vascular system after cardiac arrest. Recent advances in hemodynamic monitoring have made MSP available to the clinician through beat-by-beat cardiac output measurements during respiratory pauses under mechanical ventilation. In this way, it is possible to calculate MSP, the pressure gradient and the venous return resistances. The investigators aim is to explain the hemodynamic variations and the decrease in cardiac output observed during prone position. The investigators hypothesis is that venous return resistances are increased during prone position probably following an increased intra-abdominal pressure.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-10-01
• Study First Submitted QC: 2013-10-07
• Study First Posted: 2013-10-08
• Study Start: 2013-12
• Status Verified: 2015-09
• Last Update Submitted: 2015-09-29
• Last Update Posted: 2015-09-30
• Primary Completion: 2016-10
• Study Completion: 2016-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Prone position neurosurgery
• High-risk neurosurgery

Exclusion Criteria

• Emergency surgery
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mean systemic pressure variation	during surgery after the patient is put in prone position	change of mean systemic pressure from supine position to prone position during surgery

Secondary Outcome Measures

Name	Time	Method
intravesical pressure variation	during surgery during surgery after the patient is put in prone position	Change of intravesical pressure from supine position to prone position during surgery
intrathoracic pressure variation	during surgery during surgery after the patient is put in prone position	Change of intrathoracic pressure from supine position to prone position during surgery

Trial Locations

Locations (1)

University Hospital of Strasbourg; 🇫🇷 Strasbourg, France