Oxytocin Effects on Likeability After Being Liked or Disliked

Not Applicable

Completed

• Conditions: Social Behavior
• Interventions: Drug: Placebo; Drug: Oxytocin

• Registration Number: NCT02745431
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

The current study aimed to investigate oxytocin effect on the response after the experience of being liked or disliked.

Detailed Description

In a double-blind, between-subject, placebo controlled design study, the researchers aimed to investigate the intranasal OXT (40IU) treatment on rating response after being liked or disliked in healthy male subjects. All subjects completed a range of questionnaires measuring personality and affective traits and levels of anxiety: Positive and Negative Affect Schedule (PANAS) , State-Trait Anxiety Inventory (STAI) , Beck Depression Inventory (BDI), Cheek and Buss shyness Scale (CBSS),Autism Spectrum Quotient (ASQ), Empathy Quotient(EQ) before self-administration.Study participants were led to believe that other participants had formed an opinion on their likability based on their appearance in a photograph and they passively viewed the responses (like or dislike) from 'other participants'. After that, they rated 'other participants' about likeability (how much do you like the person), accuracy (have you seen the person), feeling (how good do you feel), and tendency (how much would do like have him/her as a friend). Likeability, tendency, feeling and accuracy were included into analysis as dependent variables.

Study Timeline

• Study Start: 2015-06
• Study First Submitted: 2016-04-15
• Study First Submitted QC: 2016-04-15
• Study First Posted: 2016-04-20
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Status Verified: 2016-11
• Last Update Submitted: 2017-07-29
• Last Update Posted: 2017-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 86

Inclusion Criteria

• Healthy subjects without past or current psychiatric or neurological disorder

Exclusion Criteria

• history of head injury;
• claustrophobia;
• medical or psychiatric illness.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Placebo nasal spray	Placebo	Placebo nasal spray
Oxytocin nasal spray	Oxytocin	Oxytocin nasal spray

Primary Outcome Measures

Name	Time	Method
Oxytocin effect on likeability after being liked or disliked	2 hour	Likeability rating was included into analysis as dependent factor.

Secondary Outcome Measures

Name	Time	Method
Relationship status may influence oxytocin effect	2 hour	subjects were subdivided into two subgroups

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology; 🇨🇳 Chengdu, Sichuan, China