Do people who have anaphylactic reactions to insect stings or foods have specific forms of genes for hormones involved in controlling blood pressure?
Not Applicable
Completed
- Conditions
- Anaphylactic shockInjury, Occupational Diseases, Poisoning
- Registration Number
- ISRCTN10465389
- Lead Sponsor
- R&D department at St Helier Hospital
- Brief Summary
1. 2012 results in https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536050/ (added 28/01/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 260
Inclusion Criteria
Anaphylaxis patients:
1. Wasp- and bee-induced anaphylaxis (>50) or food-induced allergy with anaphylaxis (>50)
Control participants:
2. Food allergy without anaphylaxis (>30) or atopic without food allergies (>30) or non-atopic control (>100)
Exclusion Criteria
1. Pregnant
2. Taking drugs that would affect the renin-angiotensin system and levels of blood hormones
3. Involved in any other studies which would be either disadvantageous to the participant's health or the benefit of the study
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Serum ACE level<br> 2. Plasma renin level<br> 3. Plasma angiotensin-1 level<br> 4. Polymorphisms of genes related to the renin angiotensin system including ACE, renin, angiotensinogen (AGT235), chymase CMI-1903, AT-2 receptor<br>
- Secondary Outcome Measures
Name Time Method