Stress in Couples Undergoing Assisted Reproduction Technology With Donor Insemination and Its Impact on Reproductive Outcomes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility, Male
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Implantation rate
- Last Updated
- 4 years ago
Overview
Brief Summary
Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients.The purpose of this study is to investigate the stress faced by participants undergoing assisted reproduction with donor sperm and to further investigate its impact on pregnancy outcomes.
Detailed Description
The number of infertility patients has increased significantly in recent years, and infertility caused by the male partner accounts for about 30%-50% of infertility factors. Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients. Many factors such as social, marital, and family problems may contribute to their depressed emotional state. And the impact of these negative emotions on pregnancy outcomes cannot be ignored. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with donor sperm to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Female partners' \>18\< 40 years
- •Male partners' \>18\< 40 years
- •Patients undergoing assisted reproductive technology with donor sperm or husband's semen due to male factor
Exclusion Criteria
- •Female partners with polycystic ovary
- •Female partners with insufficiency or premature ovarian failure
- •Female partners with endometriosis
- •Female partners with abnormal profile of thyroid hormones
- •Chromosomal abnormalities of either spouse
- •Mental disorder of either spouse
Outcomes
Primary Outcomes
Implantation rate
Time Frame: 8 months
Implantation rate is defined as number of sacs per embryo transferred.
clinical pregnancy rate
Time Frame: 8 months
presence of at least one gestational sac on ultrasound of 6 weeks
Secondary Outcomes
- fertilization rate(8 months)
- cleavage rate(8 months)
- Total gonadotropin use(8 months)
- Metaphase II (MII) oocytes(8 months)
- Ovarian hyperstimulation syndrome (OHSS) rates(8 months)
- Number of oocytes retrieved(8 months)