Stress in Couples Undergoing Assisted Reproduction Technology With Donor Insemination and Its Impact on Reproductive Outcomes
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Implantation rate
研究概览
简要总结
Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients.The purpose of this study is to investigate the stress faced by participants undergoing assisted reproduction with donor sperm and to further investigate its impact on pregnancy outcomes.
详细描述
The number of infertility patients has increased significantly in recent years, and infertility caused by the male partner accounts for about 30%-50% of infertility factors. Donor sperm provides a viable option for patients with significant male factor infertility. However, since the source of sperm is not from the male partner, the psychological burden of these couples is more pronounced and complex than other patients. Many factors such as social, marital, and family problems may contribute to their depressed emotional state. And the impact of these negative emotions on pregnancy outcomes cannot be ignored. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with donor sperm to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Female partners' >18< 40 years
- •Male partners' >18< 40 years
- •Patients undergoing assisted reproductive technology with donor sperm or husband's semen due to male factor
排除标准
- •Female partners with polycystic ovary
- •Female partners with insufficiency or premature ovarian failure
- •Female partners with endometriosis
- •Female partners with abnormal profile of thyroid hormones
- •Chromosomal abnormalities of either spouse
- •Mental disorder of either spouse
结局指标
主要结局
Implantation rate
时间窗: 8 months
Implantation rate is defined as number of sacs per embryo transferred.
clinical pregnancy rate
时间窗: 8 months
presence of at least one gestational sac on ultrasound of 6 weeks
次要结局
- fertilization rate(8 months)
- cleavage rate(8 months)
- Total gonadotropin use(8 months)
- Metaphase II (MII) oocytes(8 months)
- Ovarian hyperstimulation syndrome (OHSS) rates(8 months)
- Number of oocytes retrieved(8 months)