Stress in Couples Undergoing Assisted Reproduction Technology With Different Cycles and Its Impact on Pregnancy Outcomes
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring through assisted reproductive technology. However, a growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. The purpose of this study is to investigate the stress faced by participants undergoing ART with different cycles and to further investigate its impact on pregnancy outcomes.
详细描述
With the rapid social and economic development in recent years, the incidence of infertility has increased significantly due to environmental pollution, poor lifestyle habits and increasing stress in various areas. According to global statistics, one in six married couples suffers from infertility. With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring. In clinical practice, however, a significant proportion of patients undergoing ART have low embryo implantation and pregnancy rates and experience recurrent implantation failure (RIF). A growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. This effect is more pronounced in patients with multiple failed transfers. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with different cycles to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 40 Years(Child, Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Female partners' >18< 40 years
- •Patients undergoing assisted reproductive technology
排除标准
- •Female partners with polycystic ovary
- •Female partners with insufficiency or premature ovarian failure
- •Female partners with endometriosis
- •Female partners with abnormal profile of thyroid hormones
- •Chromosomal abnormalities of either spouse
- •Mental disorder of either spouse
结局指标
主要结局
clinical pregnancy rate
时间窗: 6 months
presence of at least one gestational sac on ultrasound of 6 weeks
Implantation rate
时间窗: 6 months
Implantation rate is defined as number of sacs per embryo transferred.
次要结局
- Metaphase II (MII) oocytes(6 months)
- Total gonadotropin use(6 months)
- Ovarian hyperstimulation syndrome (OHSS) rates(6 months)
- fertilization rate(6 months)
- cleavage rate(6 months)
- Number of oocytes retrieved(6 months)
研究者
Yimin Zhu
Chief Physician
Women's Hospital School Of Medicine Zhejiang University
