Stress in Couples Undergoing Assisted Reproduction Technology With Different Cycles and Its Impact on Pregnancy Outcomes
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- clinical pregnancy rate
- Last Updated
- 4 years ago
Overview
Brief Summary
With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring through assisted reproductive technology. However, a growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. The purpose of this study is to investigate the stress faced by participants undergoing ART with different cycles and to further investigate its impact on pregnancy outcomes.
Detailed Description
With the rapid social and economic development in recent years, the incidence of infertility has increased significantly due to environmental pollution, poor lifestyle habits and increasing stress in various areas. According to global statistics, one in six married couples suffers from infertility. With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring. In clinical practice, however, a significant proportion of patients undergoing ART have low embryo implantation and pregnancy rates and experience recurrent implantation failure (RIF). A growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. This effect is more pronounced in patients with multiple failed transfers. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with different cycles to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
Investigators
Yimin Zhu
Chief Physician
Women's Hospital School Of Medicine Zhejiang University
Eligibility Criteria
Inclusion Criteria
- •Female partners' \>18\< 40 years
- •Patients undergoing assisted reproductive technology
Exclusion Criteria
- •Female partners with polycystic ovary
- •Female partners with insufficiency or premature ovarian failure
- •Female partners with endometriosis
- •Female partners with abnormal profile of thyroid hormones
- •Chromosomal abnormalities of either spouse
- •Mental disorder of either spouse
Outcomes
Primary Outcomes
clinical pregnancy rate
Time Frame: 6 months
presence of at least one gestational sac on ultrasound of 6 weeks
Implantation rate
Time Frame: 6 months
Implantation rate is defined as number of sacs per embryo transferred.
Secondary Outcomes
- Metaphase II (MII) oocytes(6 months)
- Total gonadotropin use(6 months)
- Ovarian hyperstimulation syndrome (OHSS) rates(6 months)
- fertilization rate(6 months)
- cleavage rate(6 months)
- Number of oocytes retrieved(6 months)