Stress in Couples Undergoing Assisted Reproduction Technology With Different Cycles and Its Impact on Pregnancy Outcomes
- Conditions
- Infertility
- Interventions
- Other: cycles
- Registration Number
- NCT05055245
- Brief Summary
With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring through assisted reproductive technology. However, a growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. The purpose of this study is to investigate the stress faced by participants undergoing ART with different cycles and to further investigate its impact on pregnancy outcomes.
- Detailed Description
With the rapid social and economic development in recent years, the incidence of infertility has increased significantly due to environmental pollution, poor lifestyle habits and increasing stress in various areas. According to global statistics, one in six married couples suffers from infertility. With the development of assisted reproductive technology (ART), more and more infertile women are obtaining their offspring. In clinical practice, however, a significant proportion of patients undergoing ART have low embryo implantation and pregnancy rates and experience recurrent implantation failure (RIF). A growing number of national and international studies have shown that infertility patients are prone to negative emotions such as anxiety and depression during ART treatment, which not only affects their physical and mental health, but also affects the embryo implantation rate and pregnancy rate of ART. This effect is more pronounced in patients with multiple failed transfers. In this study, investigators intend to investigate the stress faced by participants undergoing assisted reproduction with different cycles to provide a reliable basis for future psychological interventions and health education for this group of patients and improve the quality of life of infertility patients.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 200
- Female partners' >18< 40 years
- Patients undergoing assisted reproductive technology
- Female partners with polycystic ovary
- Female partners with insufficiency or premature ovarian failure
- Female partners with endometriosis
- Female partners with abnormal profile of thyroid hormones
- Chromosomal abnormalities of either spouse
- Mental disorder of either spouse
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients undergoing assisted reproductive technology cycles Patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI)
- Primary Outcome Measures
Name Time Method clinical pregnancy rate 6 months presence of at least one gestational sac on ultrasound of 6 weeks
Implantation rate 6 months Implantation rate is defined as number of sacs per embryo transferred.
- Secondary Outcome Measures
Name Time Method Metaphase II (MII) oocytes 6 months the number of mature oocytes
Total gonadotropin use 6 months Total gonadotropin use of each participant
Ovarian hyperstimulation syndrome (OHSS) rates 6 months OHSS rates in both study groups
fertilization rate 6 months No. of fertilized oocyte divided by No. of inseminated cumulus-oocyte complexes (COCs)
cleavage rate 6 months No. of cleaved embryo divided by No. of fertilized oocyte
Number of oocytes retrieved 6 months
Trial Locations
- Locations (1)
Women's Hospital, School of Medicine, Zhejiang University
🇨🇳Hangzhou, Zhejiang, China