Effect of Assisted Reproductive Technology on Cardiac Development in Childhood Assessed by Echocardiography
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Assisted Reproductive Technology
- Sponsor
- Nanjing Medical University
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- cardiovascular geometric morphology between controls and ART children
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Assisted reproductive technology (ART) has extensively allowed pregnancy for infertile couples. However, the long-term effect of ART exposure on cardiovascular development and potential association with ART procedure and parental factors is confused. The aim is to shed more light on the pattern and extent of cardiovascular developmental alteration among ART children and its association with potential confounders.
Detailed Description
A historic cohort study was designed with prospective follow-up of ART children conceived in the Clinical Centre of Reproductive Medicine (CCRM) and born in Maternal-Fetal Medicine Unit (MFMU) of First Affiliated Hospital of Nanjing Medical University (FAHNMU) from 1 January 2002 to 31 December 2012. The present design is a prospective single-center study in FAHNMU. ART group will be recruited by a non-random, consecutive sample on the basis of the unique personal identification number assigned to ART children conceived in CCRM and born in MFMU. The controls will be recruited by a non-random, consecutive sample on the basis of the spontaneous conception population attending the MFMU of FAHNMU during the same period as ART group for prenatal screening and subsequent delivery considering their age.
Investigators
Hong Liu
Principal Investigator
Nanjing Medical University
Eligibility Criteria
Inclusion Criteria
- •the capability of complete examination of transthoracic echocardiography
- •the absence of complex cardiac malformations and systematic diseases.
Exclusion Criteria
- •the presence of a history of systemic diseases, frequent arrhythmias, and critical acquired heart diseases,
- •the presence of the background of familiar cardiomyopathy in their family,
- •limited acquisitions of echocardiographic imaging
- •poor image quality for assessment.
Outcomes
Primary Outcomes
cardiovascular geometric morphology between controls and ART children
Time Frame: participants will be followed for the duration of hospital stay, an expected average of 3 weeks
Left ventricular end-diastolic diameters (LVDD) and end-systolic diameters (LVSD) will be measured by M-mode echocardiography at the para-sternal long-axis views. LV end-diastolic volume (LVEDV) and end-systolic volume(LVESV) will be calculated by 2D echocardiography from the apical four-chamber view using the modified Simpson's rule. Aorta diameters (AOD) and left atrial diameters (LAD) will be measured by 2D echocardiography at the para-sternal long-axis views. Left and right coronary artery will be measured by 2D echocardiography at the short-axis views. The interventricular septum thickness (IVST) and the left ventricular posterior wall thickness (LVPWT) will be measured by M mode from a para-sternal long-axis view. Left ventricular relative wall thickness (LVRWT) will be calculated the following equation: (IVST+PWT)/ LVDD.
Secondary Outcomes
- cardiac function between controls and ART children(participants will be followed for the duration of hospital stay, an expected average of 3 weeks)