A Registry on Outcomes in Women Undergoing Assisted Reproductive Techniques After Recurrent Failures
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Infertility
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
- Enrollment
- 624
- Locations
- 1
- Primary Endpoint
- Number of live births
- Last Updated
- 7 years ago
Overview
Brief Summary
Assisted Reproductive Technologies (ARTs) are widely used in couples with fertility problems. However, despite ART treatment options have evolved over time, the implantation rate remains rather low.
A possible role for inherited and acquired thrombophilias has been invoked, especially in women with previous implantation failures. However, several factors could play a role in these conditions.
A potential benefit of low-molecular-weight heparin (LMWH) in improving ART outcomes, independently of the presence of thrombophilia, has been recently suggested.
This register is designed in order to better define all possible variables influencing ART outcome and improve clinical management of women with previous implantation failures. During this study the investigators will collect and evaluate clinical data regarding the first cycle in women with previous ART failures.
Investigators
Elvira Grandone, MD, Head of Unit
Head of Unit
Casa Sollievo della Sofferenza IRCCS
Eligibility Criteria
Inclusion Criteria
- •2 or more implantation failures/losses of clinical pregnancies after ART
- •ART cycle at enrolment
- •Informed consent
Exclusion Criteria
- •Ovarian hypofunction
- •Uterine pathology
- •Hydrosalpinges
- •Previous inclusion in the study
Outcomes
Primary Outcomes
Number of live births
Time Frame: 10 months
Secondary Outcomes
- Number of clinical pregnancies after ART(10 months)