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Clinical Trials/NCT02685800
NCT02685800
Unknown
Not Applicable

A Registry on Outcomes in Women Undergoing Assisted Reproductive Techniques After Recurrent Failures

Casa Sollievo della Sofferenza IRCCS1 site in 1 country624 target enrollmentOctober 2015
ConditionsInfertility

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Infertility
Sponsor
Casa Sollievo della Sofferenza IRCCS
Enrollment
624
Locations
1
Primary Endpoint
Number of live births
Last Updated
7 years ago

Overview

Brief Summary

Assisted Reproductive Technologies (ARTs) are widely used in couples with fertility problems. However, despite ART treatment options have evolved over time, the implantation rate remains rather low.

A possible role for inherited and acquired thrombophilias has been invoked, especially in women with previous implantation failures. However, several factors could play a role in these conditions.

A potential benefit of low-molecular-weight heparin (LMWH) in improving ART outcomes, independently of the presence of thrombophilia, has been recently suggested.

This register is designed in order to better define all possible variables influencing ART outcome and improve clinical management of women with previous implantation failures. During this study the investigators will collect and evaluate clinical data regarding the first cycle in women with previous ART failures.

Registry
clinicaltrials.gov
Start Date
October 2015
End Date
September 2020
Last Updated
7 years ago
Study Type
Observational
Sex
Female

Investigators

Sponsor
Casa Sollievo della Sofferenza IRCCS
Responsible Party
Principal Investigator
Principal Investigator

Elvira Grandone, MD, Head of Unit

Head of Unit

Casa Sollievo della Sofferenza IRCCS

Eligibility Criteria

Inclusion Criteria

  • 2 or more implantation failures/losses of clinical pregnancies after ART
  • ART cycle at enrolment
  • Informed consent

Exclusion Criteria

  • Ovarian hypofunction
  • Uterine pathology
  • Hydrosalpinges
  • Previous inclusion in the study

Outcomes

Primary Outcomes

Number of live births

Time Frame: 10 months

Secondary Outcomes

  • Number of clinical pregnancies after ART(10 months)

Study Sites (1)

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