The significance of the state of muscularis mucosae (MM grade) as a new risk factor for nodal metastasis in considering the indication for additional surgical colectomy with lymph node dissection among submucosal-invasive (T1) colorectal carcinomas after endoscopic treatment
- Conditions
- Colorectal carcinomas
- Registration Number
- JPRN-UMIN000011974
- Lead Sponsor
- Showa University Northern Yokohama Hospital
- Brief Summary
Results: MM grade was associated with nodal metastasis (p = 0.026), and no patients with MM grade 1 lesions had nodal metastasis. Significant risk factors for nodal metastasis in patients with MM grade 2 lesions were attribution of female (p = 0.006), lymphovascular infiltration (p < 0.001), tumor budding (p = 0.045), and poorly differentiated adenocarcinoma or mucinous carcinoma (p = 0.007). Nodal metastasis occurred in 1.06% of lesions without any of these pathological factors, but in 10.3% and 20.1% of lesions with at least one factor in male and female patients, respectively. There was good inter-observer agreement for MM grade evaluation, with a kappa value of 0.67. Conclusions: Stratification using MM grade, pathological factors and patient sex provided more appropriate indication for additional surgery with lymph node dissection after endoscopic treatment for T1 colorectal carcinomas.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 800
Not provided
People not grown up
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To clarify pathological risk factors for lymph node metastasis of T1 colorectal cancers, confirming the significance of the state of muscularis mucosae (MM grade).
- Secondary Outcome Measures
Name Time Method To establish the indication for additional surgical colectomy with lymph node dissection, based on the pathological risk factors of the excised specimen after endoscopic treatment.