Bispectral index guided induction of general anaesthesia in patients scheduled for major abdominal surgery: propofol versus etomidate
- Conditions
- General anaesthesia in major abdominal surgerySurgeryGeneral anaesthesia
- Registration Number
- ISRCTN68690518
- Lead Sponsor
- niversity Medical Centre Maribor (Slovenia)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
1. Aged over 40 years, either sex
2. American Society of Anasthesiologists (ASA) grade III
3. Scheduled for major abdominal surgery (large bowel resection, stomach resection, liver resection, Whipple resection)
All patients will get an epidural catheter in the lower half of the thoracic spine.
1. Alcohol-abuse
2. Drug abuse
3. Chronic use of benzodiazepines, opioides or other psychotrophic substances
4. Body mass index greater than 30
5. Anticipated difficult intubation (Mallampati 3 and 4)
6. Kidney disease (serum kreatinin greater than 120 mmol/l)
7. Manifest liver disease
8. Alzheimer disease
9. Epilepsy
10. Left ventricle ejection fraction less than 30%
11. Haemodynamic important heart valve disease
12. Pacemaker
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measured from the start of induction till 10 minutes after intubation:<br>1. Middle arterial pressure<br>2. Pulse<br>3. Cardiac output<br>4. Bispectral index<br>5. Oxygen saturation of haemoglobin
- Secondary Outcome Measures
Name Time Method 1. Dose of each induction agent<br>2. Time from start of anaesthesia induction to laryngoscopy and intubation<br>3. Dose of each needed rescue drug