4D PET/CT in Diagnosing Participants With Lung and Colorectal Cancer With Liver and Lung Metastasis

Completed

• Conditions: Stage IVB Lung Cancer AJCC v8; Stage IV Colorectal Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Colorectal Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Metastatic Malignant Neoplasm in the Liver; Metastatic Malignant Neoplasm in the Lung; Stage IVB Colorectal Cancer AJCC v8; Stage IVC Colorectal Cancer AJCC v8
• Interventions: Procedure: 4-Dimensional Computed Tomography; Procedure: 4D PET Scan

• Registration Number: NCT00862680
• Lead Sponsor: M.D. Anderson Cancer Center

Brief Summary

This trial studies how well 4 dimensional (D) positron emission tomography/computed tomography (PET/CT) works in diagnosing participants with lung or colorectal cancer that has spread to the liver and lung. Diagnostic procedures, such as PET/CT, may help find and diagnose disease and find out how far the disease has spread. But the motions made by breathing can reduce the image quality of the scan. Adjusting the scanner to 4D may allow for more breathing motion may improve the quality of the PET/CT images.

Detailed Description

PRIMARY OBJECTIVES:

I. Study the impact of 4D positron emission tomography/computed tomography (PET/CT) imaging on the evaluation and staging of lung and colorectal cancer.

OUTLINE:

Participants undergo 4D PET/CT scan over up to 12 minutes.

Study Timeline

• Study Start: 2009-03-12
• Study First Submitted: 2009-03-16
• Study First Submitted QC: 2009-03-16
• Study First Posted: 2009-03-17
• Primary Completion: 2019-04-28
• Study Completion: 2019-04-28
• Status Verified: 2020-04
• Last Update Submitted: 2020-04-10
• Last Update Posted: 2020-04-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Patients with suspected colorectal cancer with nodules in the lung or liver (1-2 cm in diameter) will be eligible for this study.
• Patients with suspected lung cancer with nodules in the lung or liver (1-2 cm in diameter) will be eligible for this study.

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Exclusion Criteria

• Patients that cannot tolerate being scanned for an additional 12 minutes with arms above their head will be excluded.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Diagnostic (4D PET/CT)	4-Dimensional Computed Tomography	Participants undergo 4D PET/CT scan over up to 12 minutes.
Diagnostic (4D PET/CT)	4D PET Scan	Participants undergo 4D PET/CT scan over up to 12 minutes.

Primary Outcome Measures

Name	Time	Method
Maximum lesion standardized uptake value (SUVmax) for gated and ungated positron emission tomography/computed tomography (PET/CT) scans	Up to 10 years	Will be compared using a one-sided paired t-test.
Impact of the difference in SUVmax on the lesion detectability and staging of the evaluated patients	Up to 10 years	two nuclear medicine physicians will assess the impact of the difference in SUVmax on the lesion detectablility and staging of the evaluated patients.

Trial Locations

Locations (1)

M D Anderson Cancer Center; 🇺🇸 Houston, Texas, United States