NCT01539928Unknown不适用
Dual PET/CT Imaging in Lung Cancer (Danish Title: En og Tre Timers FDG-PET/CT Ved Lungecancer)
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 216
- 试验地点
- 1
- 主要终点
- Sensitivity, specificity and accuracy
研究概览
简要总结
The purpose of this study is to compare conventional PET/CT scan performed 1 hour after injection of the radioactive tracer FDG (PET/CT[1]) with PET/CT performed after 3 hours (PET/CT[3]) in a group of patients with biopsy verified lung cancer or high suspicion of lung cancer after initial work-up (chest x-ray and CT of thorax/upper abdomen), who are potentially operable.
详细描述
The investigators also want to:
- To find the sensitivity, specificity and accuracy in PET/CT 1h and 3 h in the staging of lung cancer (N-/M-stage). Our gold standard is pathology, when not possible - follow-up (se Gold Standard 6.1.1)
- To compare SUVmax with the expression of GLUT1 and G-6-Pase in tumors
- To compare the expression of GLUT1 with the activity of G6Pase
- To compare SUVmax, RI, tumor/liver ratio, GLUT1 and G-6-Pase with the occurrence of relapse within a year after curative surgery
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cytologic/histologic-verified lung cancer or high suspicion of lung cancer after initial work up
- •Candidate to curative intended surgery after initial work up (usually chest x-ray, CT of chest/upper abdomen and if needed spirometry).
排除标准
- •Former lung cancer
- •Contraindications for PET/CT: Pregnancy, recent chemoradiotherapy
- •Diabetes mellitus.
结局指标
主要结局
Sensitivity, specificity and accuracy
时间窗: After staging or 1 year of follow up
To find the sensitivity, specificity and accuracy in PET/CT 1h and 3 h in the staging of lung cancer (N-/M-stage). Our gold standard is pathology, when not possible - follow-up
次要结局
- Occurence of relapse(1 year follow up after surgery)
研究者
Mie Holm Vilstrup
Principal investigator, MD
Odense University Hospital
研究点 (1)
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