Comparison of 18-F Sodium Fluoride Uptake in Culprit Plaques Between Acute Coronary Syndrome and Stable Angina

Not Applicable

Terminated

• Conditions: Coronary Artery Diseases

• Registration Number: NCT01665248
• Lead Sponsor: CHEOL WHAN LEE, MD, PhD.

Brief Summary

The purpose of this study is to evaluate the correlations between active calcification and vulnerable plaque.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2012-08-13
• Study First Submitted QC: 2012-08-13
• Study First Posted: 2012-08-15
• Primary Completion: 2013-05
• Study Completion: 2013-05
• Status Verified: 2014-07
• Last Update Submitted: 2014-07-25
• Last Update Posted: 2014-07-28

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Age more than 20
• Acute coronary syndrome or stable angina

Exclusion Criteria

• Contraindications to the use of heparin, aspirin, clopidogrel, stainless metal, contrast media
• Acute ST segment elevation myocardial infarction within 12hours, heart failure, cardiac shock
• Any serious medical comorbidity such that the subject's life expectancy is less than 24 months
• Ejection fraction less than 30
• Serum creatinine level of 1.5mg/dl and over
• Vasculitis
• Unwillingness or inability to cooperate or to give informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Standardized 18F-NaF uptake value within the culprit plaque	At the time of diagnosis

Secondary Outcome Measures

Name	Time	Method
The relationship between 18F-NaF uptake value and plaque types by Multidetector Computed Tomography	at the time of diagnosis
The relationship between 18F-NaF uptake value and calcium scores by Multidetector Computed Tomography	at the time of diagnosis
The relationship between 18F-NaF uptake value and biomarkers	at the time of diagnosis	hs-CRP, Troponin-I
The relationship between 18F-NaF uptake value and invasive imagings	at the time of diagnosis	Intravascular ultrasound, Optical coherence tomography

Trial Locations

Locations (1)

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of