Pathophyisiology of nocturnal gastro-esophageal reflux events and the effects of sleep medications and proton pump inhibitor on nocturnal gastro-esophageal reflux events
Not Applicable
- Conditions
- Gastro-esophageal reflux disease Sleep disorders Healthy subjects
- Registration Number
- JPRN-UMIN000013480
- Lead Sponsor
- Gunma University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 75
Inclusion Criteria
Not provided
Exclusion Criteria
1. past history of surgery on upper GI tract 2. past history of surgery on nasal cavities 3. taking medications which may affect motility of upper GI tract 4. having neuromuscular diseases 5. haing GI motility disorders 6. cannot stop taking sleep medications 7. having diseases in which interventions cannot be apllied 8. pregnant or nurcing status 9. subjects who are not appropriate for this study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number of nocturnal gastro-esophageal reflux events
- Secondary Outcome Measures
Name Time Method The number of transient lower esophageal sphincter relaxation events The number of esophago-pahryngeal reflux events The number of arousals