Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study

University of Aarhus1 site in 1 country9 target enrollmentMarch 2015

ConditionsKetone Body Metabolism Brain Metabolism

Interventionsplacebo ketone

Drugsketone placebo

Overview

Phase: Not Applicable
Intervention: placebo
Conditions: Ketone Body Metabolism
Sponsor: University of Aarhus
Enrollment: 9
Locations: 1
Primary Endpoint: Glucose metabolism in brain, CMR
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.

Hypotheses

Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.
Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.
Altered oxygen consumption during hyperketonemia in healthy subjects.

Registry

clinicaltrials.gov

Start Date

March 2015

End Date

January 2016

Last Updated

10 years ago

Study Type

Interventional

Study Design

Crossover