NCT02357550已完成不适用
Ketones Influence on Glucose Metabolism in Brain. A Human Positron Emission Tomography (PET) Study
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Glucose metabolism in brain, CMR
研究概览
简要总结
This project tend to investigate the affection of ketone bodies on brain metabolism. This will be done by measuring human cerebral uptake of energy substrates, together with functional parameters, using PET imaging and appropriate radiotracers under hyperketonemia in healthy subjects by ketone infusion.
Hypotheses
- Increased levels of ketone bodies in healthy subjects leads to decreased glucose uptake by brain cells contributing to hyperglycaemia.
- Increased levels of ketone bodies in healthy subjects leads to increased cerebral blood flow.
- Altered oxygen consumption during hyperketonemia in healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 20-30 kg/m2
排除标准
- •alcohol abuse
- •severe comorbidity
- •blood donation 6 month prior
- •claustrophobia
研究组 & 干预措施
Control
Placebo Comparator
Saline infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy
干预措施: placebo (Drug)
Hyperketonaemia
Experimental
Ketone infusion. FDG-PET Scan. O2-PET scan. H2O-PET scan Muscle biopsy
干预措施: ketone (Drug)
结局指标
主要结局
Glucose metabolism in brain, CMR
时间窗: t=240-360 minutes
cerebral glucose metabolism measured by PET tracer during the above time frame
次要结局
- Stress metabolism(0-360 minutes)
- Oxygen use(T=150-200 minutes)
- cerebral blood flow(t=180-250 minutes)
- Intramuscular signaling(t= 260 minutes)
研究者
研究点 (1)
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