How Orally Consumed 3-hydroxybuturate Alters Metabolism

Not Applicable

Completed

• Conditions: Acute Ketosis
• Interventions: Other: 3-hydroxybuturate; Other: Placebo

• Registration Number: NCT02917252
• Lead Sponsor: University of Aarhus

Brief Summary

This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.

Detailed Description

Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.

Placebo: subjects drink saline. Same sampling as on intervention day.

Study Timeline

• Status Verified: 2016-09
• Study First Submitted: 2016-09-27
• Study First Submitted QC: 2016-09-27
• Study First Posted: 2016-09-28
• Study Start: 2017-02-01
• Primary Completion: 2017-04-03
• Study Completion: 2017-04-03
• Last Update Submitted: 2017-04-07
• Last Update Posted: 2017-04-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 6

Inclusion Criteria

• BMI 20-30

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Exclusion Criteria

• Smoking
• alcohol or drug abuse
• Critically ill

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Intervention	3-hydroxybuturate	Subjects drink 3-hydroxybuturate
Placebo	Placebo	Subjects drink saline

Primary Outcome Measures

Name	Time	Method
3-hydroxybuturate	0-270 minutes	blood level of 3-hydroxybuturate

Secondary Outcome Measures

Name	Time	Method
Glucose	0-270 minutes	Glucose tracer kinetics, endogenous glucose production, muscle biopsy
lipid metabolism	0-270 minutes	Palmitate tracer kinetics, free fatty acid accumulation, adipose tissue biopsies

Trial Locations

Locations (1)

Aarhus University Hospital; 🇩🇰 Aarhus, Denmark