How Orally Consumed 3-hydroxybuturate Alters Metabolism
Not Applicable
Completed
- Conditions
- Acute Ketosis
- Registration Number
- NCT02917252
- Lead Sponsor
- University of Aarhus
- Brief Summary
This study evaluate the metabolic effects of orally ingested ketone bodies. The study is conducted as a randomized, cross over study.
- Detailed Description
Subject participate for two separate days; i) intervention, ii) placebo. Intervention: subjects drink ketone body solution. Tracer kinetics on glucose and lipid metabolism is applied. Muscle tissue and adipose tissue biopsies are taken.
Placebo: subjects drink saline. Same sampling as on intervention day.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 6
Inclusion Criteria
- BMI 20-30
Exclusion Criteria
- Smoking
- alcohol or drug abuse
- Critically ill
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method 3-hydroxybuturate 0-270 minutes blood level of 3-hydroxybuturate
- Secondary Outcome Measures
Name Time Method Glucose 0-270 minutes Glucose tracer kinetics, endogenous glucose production, muscle biopsy
lipid metabolism 0-270 minutes Palmitate tracer kinetics, free fatty acid accumulation, adipose tissue biopsies
Trial Locations
- Locations (1)
Aarhus University Hospital
🇩🇰Aarhus, Denmark
Aarhus University Hospital🇩🇰Aarhus, Denmark