Brain Activity in Adults With ADHD During Neuropsychological Tasks
- Conditions
- Attention Deficit Hyperactivity Disorder (ADHD)
- Interventions
- Device: MRI
- Registration Number
- NCT02578342
- Lead Sponsor
- Kantonsspital Aarau
- Brief Summary
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.
- Detailed Description
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.
Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
- Participant is between 20-55 years old
- Participant is not pregnant
- Participant is not able to consent him/herself
- Suspected or proven pregnancy
- Nursing
- Neurological diseases that could interfere with a diagnosis of ADHD
- Psychiatric comorbidity under treatment
- Previous history of psychiatric medication
- Substance abuse
- Intelligence quotient<75
- Claustrophobia
- Electrical simulator nerve or bone
- Implanted medication infusion pump
- Cerebral aneurysm clips
- Unstable medical condition
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy volunteers MRI healthy volunteer between age of 20 to 55 will undergo MRI examination. ADHD subjects without medication MRI Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination. ADHD subjects with medication MRI Subjects with ADHD (20-55 years), under medication will undergo MRI examination.
- Primary Outcome Measures
Name Time Method Changes in blood oxygenation level dependency (BOLD) 2 hours The study consist solely of one MRI examination performed within 2 hours.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Kantonsspital Aarau
🇨🇭Aarau, Aargau, Switzerland