Cognitive Training in Stroke Patients

Not Applicable

Active, not recruiting

• Conditions: Vascular Diseases
• Interventions: Behavioral: Cognitive training; Behavioral: Control Condition

• Registration Number: NCT03644290
• Lead Sponsor: São Paulo State University

Brief Summary

The study aims to investigate the behavioral effects, neural correlates and functional connectivity of cognitive training in patients with stroke

Detailed Description

The study will investigate the effects of two cognitive training strategies on behavior, neural correlates and functional connectivity of patients with vascular lesions. The first strategy is associated to the ability to apply efficient organizational semantic category strategy to a list of words. This strategy will be trained in activities similar to everyday life activities. There will be in total 5 sessions, two for measuring the generalization effects before and after training and three sessions to apply the semantic strategy in order to improve encoding and episodic memory performance. The second strategy is related to the ability to remember face-names and the strategy will involve the identification of a salient face feature, creation of a nickname and association of the nickname to the real name. There will be 5 sessions in total, two for measuring the generalization effects before and after training and three sessions to apply the face-name association strategy in order to improve encoding and episodic memory performance. These two cognitive training procedures will be carried out in two separate moments. Before and after each procedure all participants will be examined by functional MRI during resting state and during a active task using a memory encoding paradigm. The same procedure will be carried out with normal control participants.

Study Timeline

• Study Start: 2015-01-02
• Primary Completion: 2018-02-01
• Study First Submitted: 2018-08-16
• Study First Submitted QC: 2018-08-21
• Study First Posted: 2018-08-23
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-25
• Last Update Posted: 2023-11-28
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• people with chronic vascular ischemic lesions (more than 6 months)

Exclusion Criteria

• vascular hemorrhages, stenosis, psychiatric problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive training	Cognitive training	Semantic categorization training sessions
Control condition	Control Condition	Five sessions of behavioral control condition with information and education

Primary Outcome Measures

Name	Time	Method
Change from baseline memory performance at 6 months	up to 24 weeks after intervention	Hopkins Verbal Learning Test (episodic memory test total immediate score 48 and delayed score12) and fMRI active task (news recall immediate and delayed score 12)

Secondary Outcome Measures

Name	Time	Method
Change from baseline everyday life activity performance at 6 months	up to 24 weeks of intervention	Generalization questionnaire (questions on difficulties in everyday memory total score 12)

Trial Locations

Locations (1)

University of Sao Paulo; 🇧🇷 São Paulo, Sao Paulo, Brazil