Building a Platform for Precision Anesthesia in the Geriatric Surgical Patient

Recruiting

• Conditions: Cognitive Impairment; Cognitive Change; Anesthesia; Reaction; Anesthesia; Adverse Effect; Cognitive Decline; Postoperative Delirium
• Interventions: Combination Product: Neurocognition Interventions

• Registration Number: NCT03839784
• Lead Sponsor: Stanford University

Brief Summary

The research team is creating a foundational infrastructure in order to develop a precision medicine approach for geriatric patients who require surgery with anesthesia. The team plans to build the first of its kind comprehensive database of demographic and risk factor questionnaire responses, biobanked blood specimens, intraoperative electroencephalography (EEG), and inclusive cognitive testing throughout patient interaction starting at the preop appointment until a year later. This will be used to create a predictive model of periooperative neurocognitive disorders.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-02-11
• Study First Submitted QC: 2019-02-12
• Study First Posted: 2019-02-15
• Study Start: 2020-09-01
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-07
• Last Update Posted: 2024-08-09
• Primary Completion: 2030-08-30
• Study Completion: 2030-08-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 250

Inclusion Criteria

• At least 65 years old (inclusive)
• Non cardiac general elective surgery
• General anesthesia is expected for 2+ hours

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Exclusion Criteria

• Alzheimer's
• Dementia
• Parkinson's
• History of neurodegenerative diseases
• Medication for depression (ie. Benzodiazepines)
• Alcoholism
• Discretion of PI

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Neurocognitive Assessment Arm	Neurocognition Interventions	-

Primary Outcome Measures

Name	Time	Method
Postoperative Neurocognitive Disorders	3 years	Neurocognitive Assessment Battery

Trial Locations

Locations (1)

Stanford Medical Center; 🇺🇸 Stanford, California, United States