Establishment of precision medicine platform for early diagnosis of mild cognitive impairment

Samsung Medical Center0 sites1,000 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

January 31, 2021

Last Updated

3 years ago

Study Type

Observational Study

Sex

All

Sponsor

•1\. Adult men and women over the age of 45
•2\. After listening to and fully understanding the detailed explanation of this study, the subject or legal representative voluntarily decides to participate in the study and gives written consent
•Subjective Cognitive Dysfunction (SCD)
•1\. MMSE score above mean\-1 SD when considering age, gender, and education level
•2\. A willing and viable subject to cooperate with this study and complete all clinical trial stages
•Mild cognitive impairment (MCI)
•1\. Patient or guardian complains of cognitive impairment
•2\. Confirmation that cognitive ability including memory is lower than age and education through neuropsychological test (aMCI) Disorder (naMCI)
•3\. Maintain overall cognitive function
•4\. No disruption to daily life

•Exclusion from this study is required if one or more of the following conditions are met
•1\) Patients with neurological abnormalities that may cause memory impairment on medical examination
•2\) Those with a history of uniaxial psychiatric disorders including intellectual disability, schizophrenia, alcoholism, and bipolar disorder in the past
•3\) Those with a history of malignant disease (cancer) within the last 3 years. Except for cervical carcinoma in situ or non\-melanoma skin cancer.
•4\) Those who have undergone cerebrovascular surgery, such as brain surgery or carotid artery surgery
•5\) Those who have neurological symptoms that are evidence of cerebrovascular disease, such as extrapyramidal signs consistent with subcortical lesions.
•6\) Those who have clear white matter on MRI. Distinctive white matter should conform to the following definition. Periventricular lesions measured in parallel with the ventricles should be 10 mm or more (extended cap) or an irregular edge and an irregular halo of more than 10 mm (irregular halo). change) or a local lesion, but more than an extensive deep white matter change.
•7\) Those who have difficulty breathing when sitting still
•8\) Those who have had memory impairment, speech impairment, or problem\-solving ability for more than 2 hours after a heart attack
•9\) Those who have been hospitalized for mental or emotional illness within the past 5 years