AI-Powered Research

Normal control group in the 65-80s: Those who have normal results from health checkups, and cognitive tests (interview, neurological tests, neuropsychological tests, blood tests, brain MRI) and negative amyloid from the amyloid PET. Or asymptomatic Alzheimer's disease: Those who have normal results from health checkups, and cognitive tests (interview, neurological tests, neuropsychological tests, blood tests, brain MRI) but positive amyloid from the amyloid PET.

An elderly 65 years of age or older who meets both of the following conditions; (1) If the clinical diagnosis based on neurological examination, medical history, brain MRI test, blood test (basic blood test, thyroid test, syphilis test, vitamin test) corresponds to mild cognitive impairment due to Alzheimer's disease, (2) In the case of a positive for amyloid PET and confirmed as mild cognitive impairment due to Alzheimer's disease

An elderly 65 years of age or older who meets both of the following conditions; (1) If the clinical diagnosis based on neurological examination, medical history, brain MRI test, blood test (basic blood test, thyroid test, syphilis test, vitamin test) corresponds to Alzheimer's disease dementia, (2) Patients who test positive for amyloid PET and are diagnosed with Alzheimer's dementia

Exclusion Criteria

1) Patients with neurological abnormalities that may cause memory impairment on medical examination
2) Those who have a history of axis 1 psychiatric diseases including past intellectual disability, schizophrenia, alcoholism, and bipolar disorder
3) When it is judged that there is a problem in attaching the EEG and DC stimulation electrodes due to a deformity of the scalp, inflammatory reaction, or other dermatological problems
4) Stroke, convulsive history, current stroke or transient ischemia, convulsive disease, Parkinson's disease, multiple sclerosis, cerebral palsy, Huntington's disease, encephalitis, meningitis, diabetes which requires the insulin, poorly controlled hypertension, liver cirrhosis, or person receiving medical diagnosis and treatment that may interfere with the completion of this cognitive training program, such as kidney disease that requires dialysis
5) Those who have a history of malignant disease (cancer) within the last 3 years. However, cervical intraepithelial cancer or non-melanoma skin cancer is excluded.
6) Those who have undergone cerebrovascular surgery, such as brain surgery or carotid artery surgery
7) Those who have difficulty breathing when sitting still
8) Persons with memory, language, or problem-solving problems for more than 2 hours after a heart attack
9) Those with a history of hospitalization for mental or emotional illness within the last 5 years
10) Those with a history of abuse of drugs within the last 5 years
11) Those with a history of receiving treatment for alcoholism within the last 5 years
12) Persons who have lost consciousness for more than 1 hour due to causes other than general anesthesia
13) Those who have been hospitalized because of a head injury
14) Those who cannot read ordinary letters even with glasses due to decreased vision
15) Those who have difficulty understanding conversations due to hearing impairment even with hearing aids
16) Those who judge other investigators to be unsuitable for participation in clinical trials