Epidemiology of In-hospital Acute Kidney Injury

Recruiting

• Conditions: Dialysis; Complications; Acute Kidney Injury; Chronic Kidney Diseases
• Interventions: Other: Data collection

• Registration Number: NCT05151003
• Lead Sponsor: Universita degli Studi di Genova

Brief Summary

Retrospective observational study to investigate acute kidney injury (AKI) epidemiology and outcomes in patients hospitalized in University Hospital San Martino, Genova, Italy.

Detailed Description

A retrospective observational study was designed to investigate acute kidney injury (AKI) epidemiology and outcome in patients hospitalized in University Hospital San Martino, Genova, Italy.

All data will be extracted from the hospital electronic database. The investigators will evaluate demographic, clinical and laboratory data, including age, sex, serum creatinine (sCr), sodium and electrolytes, intensive care unit (ICU) admission, length of hospital stay, death, comorbidities and primary diagnosis codes at the hospital discharge (using International Classification of Diseases-ICD-9- codes).

The investigators will include also patients affected by Coronavirus disease 19 (COVID-19).

The primary endpoint will be to describe AKI epidemiology, secondary endpoints will be to evaluate AKI-related risk factors and clinical outcomes, such as length of stay and mortality.

Moreover, the investigators will describe the differences in the outcome and treatments of AKI patients in the medical wards and ICU.

Study Timeline

• Study Start: 2021-08-01
• Study First Submitted: 2021-11-15
• Study First Submitted QC: 2021-11-26
• Study First Posted: 2021-12-09
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-27
• Last Update Posted: 2023-11-29
• Primary Completion: 2025-08-01
• Study Completion: 2025-12-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60000

Inclusion Criteria

• Patients admitted to University Hospital San Martino, Italy
• We'll include also patients affected by Coronavirus disease 19 (COVID-19).

Exclusion Criteria

• Hemodialysis patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients admitted to University Hospital San Martino, Genova, Italy	Data collection	Adult patients admitted to University Hospital San Martino, Genova, Italy

Primary Outcome Measures

Name	Time	Method
Acute Kidney Injury incidence	Collection of retrospective data from 2016	Rate of in-hospital Acute Kidney Injury incidence
Acute Kidney Injury severity	Collection of retrospective data from 2016	Staging of in-hospital Acute Kidney Injury according to the KDIGO guidelines

Secondary Outcome Measures

Name	Time	Method
Mortality in Acute Kidney Injury patients	Collection of retrospective data from 2016	Rate of in-hospital mortality among patients with Acute Kidney Injury
Creatinine clearance after discharge	Collection of retrospective data from 2016	Data on kidney function after the discharge in Acute Kidney Injury patients

Trial Locations

Locations (1)

IRCCS Policlinico San Martino; 🇮🇹 Genova, Italy