The study on the efficacy and the mechanism of repetitive transcranial magnetic stimulation (rTMS) for mood disorders
- Conditions
- Major depression, bipolar disorder
- Registration Number
- JPRN-jRCTs072180045
- Lead Sponsor
- Tateishi Hiroshi
- Brief Summary
rTMS treatment significantly improved depressive symptom scores and some subscales of cognitive dysfunction. The partial improvement of cognitive function and the decrease of serum IL-1beta showed a significant correlation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 34
1.Patients with major depression or bipolar disorders who were ineffective for the treatment of more than one antidepressants
2.Written informed consent
Absolute contraindications are patients with metals in the brain, patients with intracardiac catheters, patients with high intracardiac pressure. Relative contraindications are epilepsy patients, patients with a history of intracranial lesions, oral history of drugs that reduce convulsion threshold, sleep deprivation, alcohol dependence, pregnant women, children, patients with severe heart disease. Regarding cerebrospinal fluid examination, patients with high risk such as bleeding tendency, heparin use, anesthesia allergy, cerebral hypertension etc., or patients judged inappropriate by the psychiatrist.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The efficacy of rTMS for patients with refractory mood disorders
- Secondary Outcome Measures
Name Time Method The changes of BDI , biomarkers in cerebrospinal fluid, blood and saliva, fractional anisotropy value, cerebral blood flow rate, cerebral cortex blood flow and oxygen consumption, frontal lobe function, electroencephalogram and their correlation.