Impact of MultiPoint Pacing Technology in CRT Patients With Reduced RV-to-LV Delay

• Conditions: Cardiac Resynchronization Therapy

• Registration Number: NCT02713308
• Lead Sponsor: Monaldi Hospital

Brief Summary

Observational, retrospective and perspective study with acute and chronic endpoints

Detailed Description

Study to assess the benefit from Multipoint Pacing (MPP) in presence of RV-to-LV delay\<80ms in terms of rate of CRT responder patients at 6 Months from CRT-D system implantation

Study Timeline

• Study First Submitted: 2016-03-15
• Study First Submitted QC: 2016-03-15
• Study First Posted: 2016-03-18
• Study Start: 2017-01
• Status Verified: 2020-03
• Last Update Submitted: 2020-03-11
• Last Update Posted: 2020-03-12
• Primary Completion: 2020-09
• Study Completion: 2021-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 248

Inclusion Criteria

• Indication to CRT-D system implantation according to current guidelines or CRT-D system already implanted in patient scheduled to CRT-D system implantation according to current guidelines

Exclusion Criteria

• Right Bundle Branch Block
• Severe Irreversible Renal Failure (eGFR<30)
• NYHA IV
• Atrio-Ventricular Block above the 1st grade
• Prosthetic Valves
• Atrial Fibrillation at implantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of CRT responder patients	6 Months	A patient is considered "responder" if Left Ventricular End-Systolic Volume at 6 Months from CRT-D system implantation is reduced at least of 15% towards the baseline value

Trial Locations

Locations (2)

Monaldi Hospital; 🇮🇹 Naples, Italy

Università della Campania "Luigi Vanvitelli"; 🇮🇹 Naples, Italy