A multicentre, prospective, randomised study to determine the effects of an exercise managed intervention (ARTEMIStudy)

Aging, Rehabilitation & Geriatric Care Research Centre (Canada)0 个研究点目标入组 720 人开始时间: 2010年2月11日最近更新: 2015年1月13日

试验速览

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•1. Male or female
•2. Aged 18 to 70 years
•3. Presents with metabolic syndrome as defined by having SBP greater than 130 mmHg and/or DBP greater than 85 mmHg and any two of the following criteria:
•3.1. Abdominal obesity (waist circumference greater than 102 cm in males; greater than 88 cm in females)
•3.2. Fasting triglycerides greater than 1.695 mmol/L
•4. Low HDL cholesterol: males less than 1.04 mmol/L; females less than 1.29 mmol/L
•5. Fasting glucose greater than 5.60 mmol/

•Any patient who:
•1. Has an in-clinic mean SBP greater than or equal to 180 mmHg and/or DBP greater than or equal to 110 mmHg
•2. Has a history of myocardial infarction, angioplasty, coronary artery bypass, or cerebrovascular ischaemia/stroke
•3. Has symptomatic congestive heart failure
•4. Has atrial flutter
•5. Has uncontrolled hypertension
•6. Has unstable angina
•7. Has unstable pulmonary disease (e.g., asthma or obstructive lung disease)
•8. Uses medications known to affect heart rate (e.g., beta-blockers)
•9. Has second or third degree heart block
•10. Has a history of alcoholism, drug abuse, or other emotional, cognitive or psychiatric problem that is likely to impair compliance to the study
•11. Requires the continuation of other medication which might interfere with the objectives of the study
•12. Has a pacemaker
•13. Has unstable metabolic disease (e.g. uncontrolled thyroid disease)
•14. Has orthopaedic or rheumatologic problems that could impair ability to exercise
•15. Has a history of allergy to any of the study drugs
•16. Started, or changed dose of, a lipid lowering agent(s) within the previous 3 months
•17. Is currently enrolled in a clinical research trial

发起方

Aging, Rehabilitation & Geriatric Care Research Centre (Canada)