Prescribing exercise for diabetes preventio

Completed

• Conditions: Metabolic syndrome; cardiovascular complications of type 2 diabetes; Nutritional, Metabolic, Endocrine; Other metabolic disorders

• Registration Number: ISRCTN50086114
• Lead Sponsor: Aging, Rehabilitation & Geriatric Care Research Centre (Canada)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02-11
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 720

Inclusion Criteria

1. Male or female
2. Aged 18 to 70 years
3. Presents with metabolic syndrome as defined by having SBP greater than 130 mmHg and/or DBP greater than 85 mmHg and any two of the following criteria:
3.1. Abdominal obesity (waist circumference greater than 102 cm in males; greater than 88 cm in females)
3.2. Fasting triglycerides greater than 1.695 mmol/L
4. Low HDL cholesterol: males less than 1.04 mmol/L; females less than 1.29 mmol/L
5. Fasting glucose greater than 5.60 mmol/

Exclusion Criteria

Any patient who:
1. Has an in-clinic mean SBP greater than or equal to 180 mmHg and/or DBP greater than or equal to 110 mmHg
2. Has a history of myocardial infarction, angioplasty, coronary artery bypass, or cerebrovascular ischaemia/stroke
3. Has symptomatic congestive heart failure
4. Has atrial flutter
5. Has uncontrolled hypertension
6. Has unstable angina
7. Has unstable pulmonary disease (e.g., asthma or obstructive lung disease)
8. Uses medications known to affect heart rate (e.g., beta-blockers)
9. Has second or third degree heart block
10. Has a history of alcoholism, drug abuse, or other emotional, cognitive or psychiatric problem that is likely to impair compliance to the study
11. Requires the continuation of other medication which might interfere with the objectives of the study
12. Has a pacemaker
13. Has unstable metabolic disease (e.g. uncontrolled thyroid disease)
14. Has orthopaedic or rheumatologic problems that could impair ability to exercise
15. Has a history of allergy to any of the study drugs
16. Started, or changed dose of, a lipid lowering agent(s) within the previous 3 months
17. Is currently enrolled in a clinical research trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified