Acute Salt Handling in Orthostatic Intolerance
- Conditions
- Orthostatic IntolerancePostural Tachycardia SyndromeOrthostatic Tachycardia
- Interventions
- Other: normal saline (0.9%)
- Registration Number
- NCT00581633
- Lead Sponsor
- Vanderbilt University
- Brief Summary
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control subjects.
- Detailed Description
Patients with chronic OI appear to be hypovolemic with abnormalities in hormones that regulate salt \& water handling. Increases in dietary salt have salutary effects on orthostatic tolerance in a physiological laboratory. The infusion of intravenous saline acutely decreased heart rate in this patient population. Preliminary data from Vanderbilt suggests abnormal salt handling in patients with chronic OI in a few patients. These data need to be confirmed and a better understanding of sodium handling in response to acute salt loads is required in these patients.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 30
- Diagnosed with orthostatic intolerance by Vanderbilt Autonomic Dysfunction Center (or healthy control subject)
- Overt or acute cause for orthostatic tachycardia
- Hypertension (BP>145/95 or need for anti-hypertensive medications)
- QRS duration > 120 msec on EKG
- Pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 normal saline (0.9%) saline infusion for sodium loading
- Primary Outcome Measures
Name Time Method Urinary Na excretion 24h and then hourly post saline load
- Secondary Outcome Measures
Name Time Method Catecholamine levels 1 day
Trial Locations
- Locations (1)
Vanderbilt University
🇺🇸Nashville, Tennessee, United States