Oral Fluid vs IV Fluid After Primary TKA

Not Applicable

Recruiting

• Conditions: Osteoarthritis, Knee; Total Knee Arthroplasty; Oral Fluid Replacement
• Interventions: Dietary Supplement: Oral fluid; Dietary Supplement: IV fluid

• Registration Number: NCT06288815
• Lead Sponsor: Thammasat University Hospital

Brief Summary

The goal of this study is to compared efficacy of oral fluid and intravenous fluid after primary unilateral total knee arthroplasty.

The main question it aims to answer is:

Does oral fluid replacement after primary unilateral total knee arthroplasty provide a patient recover faster than intravenous fluids replacement?

Detailed Description

Not available

Study Timeline

• Study Start: 2024-01-10
• Study First Submitted: 2024-02-25
• Study First Submitted QC: 2024-02-29
• Status Verified: 2024-03
• Study First Posted: 2024-03-01
• Last Update Submitted: 2024-03-01
• Last Update Posted: 2024-03-04
• Primary Completion: 2024-12
• Study Completion: 2025-06

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• Age 40-85 years old
• ASA I, II
• Primary osteoarthritis

Exclusion Criteria

• Diuretics use
• Morbid obesity
• Previous knee surgery
• Cannot undergo spinal anesthesia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Oral fluid	Oral fluid	* NPO (8hr for food, 2hr for water) * Intraoperative IV fluid at least 1 liter * Post operative (Off IV fluid, allow oral fluid as protocol at least 24hr)
IV fluid	IV fluid	* NPO (8hr for food, 2hr for water) * Intraoperative IV fluid at least 1 liter * Post operative (IV fluid as protocol at least 24hr, allow oral fluid as usual)

Primary Outcome Measures

Name	Time	Method
Time to stand and walk	Postoperative day 1	Stand and walk with walker

Secondary Outcome Measures

Name	Time	Method
the levels of blood urea nitrogen (BUN).	Postoperative day 1,2	Blood chemistry
Incidence of oliguria	Postoperative day 1,2	Urine output \< 0.5ml/kg/hr
Incidence of nausea/vomiting	Postoperative day 1,2	record symptom of nausea and vomiting
Urine specific gravity	Postoperative day 1	Urine specific gravity every 4 hours
Time up and go	24 and 48 hours	Record time since stand up and walk 3 meters, or 10 feet away, on the floor
the levels of certain electrolytes	Postoperative day 1,2	Blood chemistry
the levels of creatinine	Postoperative day 1,2	Blood chemistry
Complications	Until postoperative 3months	Pulmonary edema, heart failure, acute kidney injury

Trial Locations

Locations (1)

Thammasat University; 🇹🇭 Khlong Luang, Pathum Thani, Thailand