Choice of Treatments for Ovulation Induction Among Poor Responders

Phase 3

Conditions: Female infertility.
Female infertility associated with anovulation

Registration Number: IRCT201106026689N1

Lead Sponsor: Vice Chancellor for Research, Tehran University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 100

Inclusion Criteria

Inclusion Criteria: Infertile women with at least two episodes of poor responses following maximal stimulation or at least two of the following three conditions: 1- Advanced maternal age (40 years old or greater) 2- A history of IVF failure ( retrieved 3 oocytes or less) 3- An abnormal ovarian reserve test (Antral Follicle Count 5 or lesser in early follicular phase or Antimulerian hormone less than 1mIU/ml)

Exclusion Criteria

1-Male infertility which needs interventions such as TESE (Testicular Sperm Extraction) or PESA (Percutaneous Epididymal Sperm Aspiration) 2- Endometriosis (stage 3 or 4) 3- Uterine myoma with 4cm size or greater 4- maternal age greater than 43 years old

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The number of retrieved oocytes. Timepoint: The day of oocyte retrieval. Method of measurement: Invert Microscope, Diaphot 300, Nikon, Japan.

Secondary Outcome Measures

Name	Time	Method
Chemical Pregnancy. Timepoint: 19 days after oocyte retrieval. Method of measurement: ßhCG titration.;The number of dominant follicles. Timepoint: 48 hours prior to oocyte retrieval. Method of measurement: Transvaginal ultrasonography.;The number and quality of embryos. Timepoint: 48 hours after oocyte retrieval. Method of measurement: Invert Microscope, Diaphot 300, Nikon, Japan.;Clinical pregnancy rate. Timepoint: 33 days after oocyte retrieval. Method of measurement: observed gestational sac in transvaginal sonography.;Fertilization Rate. Timepoint: The day after oocyte retrieval. Method of measurement: (Total number of embryos/ Total number of injected oocytes)* 100.;Cancellation rate of cycle. Timepoint: Any time. Method of measurement: the number of cycles not resulted in oocyte retrieval.