comparison of dexmedetomidine and propofol sedation in IC
Phase 3
- Conditions
- Sedation in ICU patients.
- Registration Number
- IRCT20230828059291N1
- Lead Sponsor
- Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
patients over 18 years old
staying in ICU for at least 24 hours after surgery
need to be intubated and be sedated
Exclusion Criteria
Hypotension (SBP<90)
pregnant women
obesity (body weight more than 50% higher than ideal body weight)
ESRD patients
Glasgow Coma Scale (GCS) below 12 (moderate and severe brain damage)
Significant arrhythmia or high degree of atrioventricular node block
patients who are allergic to the drugs
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison of the need for narcotic drug (fentanyl) in dexmedetomidine and propofol groups. Timepoint: The amount of injected fentanyl will be measured at the end of 24 hours. Method of measurement: The amount of fentanyl injection will be recorded during the study.
- Secondary Outcome Measures
Name Time Method Respiratory parameters (respiratory rate, spontaneous breathing and airway pressure). Timepoint: Respiratory parameters will be recorded at intervals of 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours. Method of measurement: The mentioned variables are measured by ventilator devices and then recorded at the time intervals.;Level of consciousness. Timepoint: The level of consciousness will be recorded at intervals of 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours. Method of measurement: The level of consciousness will be measured by Ramsay Sedation Scale.;Hemodynamic parameters (systolic and diastolic blood pressure, heart rate, mean arterial blood pressure). Timepoint: Hemodynamic parameters will be recorded at intervals of 30 minutes, 1 hour, 3 hours, 6 hours, 12 hours and 24 hours. Method of measurement: The monitoring device.