The Correlation and Intervention of Intestinal Flora and Frailty in the Elderly
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- Frailty Syndrome
- 发起方
- Xijing Hospital
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Improvement of frailty
- 状态
- Enrolling By Invitation
- 最后更新
- 去年
概览
简要总结
The study aim to evaluate the improvement and correlation of soluble dietary fiber (prebiotics) in the frailty of elderly people by a randomized, double-blind, placebo-controlled clinical trial.
详细描述
100 healthy controls, 100 pre-frailty and 100 frailty elderly will be included. the healthy controls will be received no intervention. The pre-frailty will be randomized at a 1：1 ratio to receive prebiotics (inulin) or placebo (maltodextrin) . The degree of improvements and correlation in frailty will be evaluated three months later.Similarly,the frailty also will be randomized at a 1：1 ratio to receive prebiotics (inulin) or placebo (maltodextrin). The degree of improvements and correlation in frailty will be evaluated three months later.
研究者
Wang Xiaoming-1
Director of geriatrics
Xijing Hospital
入排标准
入选标准
- •Age ≥65 years;
- •Can get up from a chair and walk 6 meters
- •Clearly consciousness, able to read or use words to express and communicate without difficulty
- •Agree and accept the study plan
排除标准
- •Acute and chronic inflammatory disease of the intestine within 3 months
- •Use of antibiotics, probiotics, prebiotics or synthetics, laxatives or diarrhea medications, proton pump inhibitors or gastric motility drugs within 1 month
- •mental illness or blindness
- •acute infection
结局指标
主要结局
Improvement of frailty
时间窗: 3 months
Frailty will be diagnosed according to Fried criteria
次要结局
- Diversity analysis of intestinal flora(3 months)